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Snx21 Sorting nexin 21 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33466, updated on 4-Apr-2024

Summary

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Official Symbol
Snx21provided by FlyBase
Official Full Name
Sorting nexin 21provided by FlyBase
Primary source
FLYBASE:FBgn0031457
Locus tag
Dmel_CG3077
See related
AllianceGenome:FB:FBgn0031457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3077; Dmel\CG3077; DmSNX21; snx21
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in protein transport. Predicted to be active in early endosome membrane. Is expressed in organism. Orthologous to several human genes including SNX21 (sorting nexin family member 21). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
23A5-23A5; 2-7 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2763416..2765665, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2763416..2765665, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bacchus Neighboring gene long non-coding RNA:CR44772 Neighboring gene SNAP associated protein Neighboring gene HemK methyltransferase 2 Neighboring gene Transportin-Serine/Arginine rich Neighboring gene anterior pharynx defective 1 Neighboring gene TBP-associated factor 10b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Snazarus and its human ortholog SNX25 modulate autophagic flux. Lauzier A, et al. J Cell Sci, 2022 Mar 1. PMID 34821359
  2. SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Zhang P, et al. Cell Res, 2011 Dec. PMID 22041890, Free PMC Article
  3. Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Eulalio A, et al. Genes Dev, 2007 Oct 15. PMID 17901217, Free PMC Article
  4. An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. Zhang P, et al. Dev Cell, 2019 May 20. PMID 31006650, Free PMC Article
  5. Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors. Tegeder I, et al. J Neurooncol, 2019 Jan. PMID 30446899

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin 21
Names
CG3077-PA
CG3077-PB
Snx21-PA
Snx21-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2763416..2765665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273033.1 → NP_001259962.1  sorting nexin 21, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259962.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBU4
    Conserved Domains (1) summary
    cd07279
    Location:65 → 182
    PX_SNX20_21_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 20 and 21

  2. NM_134865.3 → NP_608709.1  sorting nexin 21, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RT6, Q9VQG1
    Related
    FBpp0077416
    Conserved Domains (1) summary
    cd07279
    Location:71 → 188
    PX_SNX20_21_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 20 and 21
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBU4 M9PBU4
Q9VQG1 Q9VQG1

Gene LinkOut

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