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Ddr Discoidin domain receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3346209, updated on 11-Apr-2024

Summary

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Official Symbol
Ddrprovided by FlyBase
Official Full Name
Discoidin domain receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0053531
Locus tag
Dmel_CG33531
See related
AllianceGenome:FB:FBgn0053531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11573; CG13985; CG33531; CG9488; CG9490; CT33540; ddr; DDR; Dmel\CG33531
Old locus tag
CG13984; Dmel_CG13984
Summary
Predicted to enable collagen binding activity and protein tyrosine kinase collagen receptor activity. Predicted to be involved in positive regulation of kinase activity and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung non-small cell carcinoma; osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1) and DDR2 (discoidin domain receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
26C1-26C2; 2-19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6253123..6323466)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6253123..6323466)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44823 Neighboring gene UDP-glycosyltransferase family 37 member B1 Neighboring gene Arylalkylamine N-acetyltransferase-like 2 Neighboring gene long non-coding RNA:CR46410 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PDZ domain-containing guanine nucleotide exchange factor Neighboring gene Pez

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differentiation signals from glia are fine-tuned to set neuronal numbers during development. Prasad AR, et al. Elife, 2022 Sep 12. PMID 36094172, Free PMC Article
  2. Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway. Lee JH, et al. Mol Cell Biol, 2002 Nov. PMID 12370312, Free PMC Article
  3. Discoidin domain receptor regulates ensheathment, survival and caliber of peripheral axons. Corty MM, et al. Development, 2022 Dec 1. PMID 36355066, Free PMC Article
  4. The Batten disease gene CLN3 is required for the response to oxidative stress. Tuxworth RI, et al. Hum Mol Genet, 2011 May 15. PMID 21372148, Free PMC Article
  5. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila. Sharma A, et al. Sci Rep, 2020 Nov 5. PMID 33154387, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
discoidin domain receptor
Names
CG33531-PD
CG33531-PF
CG33531-PG
Ddr-PD
Ddr-PF
Ddr-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6253123..6323466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298737.1 → NP_001285666.1  discoidin domain receptor, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DZ7
    Conserved Domains (4) summary
    smart00219
    Location:759 → 1038
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:106 → 262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:109 → 261
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd05051
    Location:753 → 1040
    PTKc_DDR; Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors

  2. NM_001014474.4 → NP_001014474.3  discoidin domain receptor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014474.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DZ7
    Conserved Domains (4) summary
    smart00219
    Location:759 → 1038
    TyrKc; Tyrosine kinase, catalytic domain
    smart00231
    Location:106 → 262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:109 → 261
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd05051
    Location:753 → 1040
    PTKc_DDR; Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors

  3. NM_001169424.2 → NP_001162895.2  discoidin domain receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162895.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHA2, G2J650
    Conserved Domains (2) summary
    smart00231
    Location:106 → 262
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:109 → 261
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHA2 E1JHA2
Q59DZ7 Q59DZ7

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