cpb capping protein beta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cpbprovided by FlyBase
Official Full Name: capping protein betaprovided by FlyBase
Primary source: FLYBASE:FBgn0011570
Locus tag: Dmel_CG17158
See related: AllianceGenome:FB:FBgn0011570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bnd; Cap2; CAPB_DROME; CapZ; CapZbeta; CG17158; CP; CP-beta; Cpb; CpB; CPB; cpbeta; Cpbeta; Dmel\CG17158; J
Summary: Enables protein heterodimerization activity. Involved in several processes, including barbed-end actin filament capping; oogenesis; and regulation of plasma membrane bounded cell projection assembly. Part of F-actin capping protein complex. Colocalizes with adherens junction. Is expressed in several structures, including embryonic/larval hemocyte; extended germ band embryo; gut section; macrochaeta; and muscle system. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 22B1-22B1; 2-3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1704902..1706962)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1704902..1706962)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that actin-capping protein subunits Cpa and Cpb stabilize each other's protein levels and can stimulate the production of each other's mRNA when the level of one of the subunit is reduced.
Title: Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.
Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.
Title: Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.
Capping protein beta is required for actin cytoskeleton organisation and cell migration during Drosophila oogenesis
Title: Capping protein beta is required for actin cytoskeleton organisation and cell migration during Drosophila oogenesis.
the actin-capping protein heterodimer, which regulates actin filament polymerization, has a dual function on DE-cadherin in restricted epithelia
Title: A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis.
findings show an interdependency between Hpo signaling activity and F-actin dynamics in which CP and Hpo pathway activities inhibit F-actin accumulation, and the reduction in F-actin in turn sustains Hpo pathway activity
Title: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila.
two actin regulators, capping protein, a barbed end binding protein, and the Arp2/3 complex, a potent actin assembly nucleator, function to generate properly organized bundles.
Title: Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development.
Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration.
Title: Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in barbed-end actin filament capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IC Inferred by Curator more info	PubMed
involved_in negative regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament length	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of F-actin capping protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of F-actin capping protein complex	IEA Inferred from Electronic Annotation more info
part_of WASH complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: capping protein beta

Names: CG17158-PA; CG17158-PB; CP beta subunit; Capping-protein-beta; F-actin capping protein; actin capping protein; actin capping protein beta; actin-capping protein; ancpbeta; burned; capping protein; capping proteinbeta; capping proteins beta; cpb-PA; cpb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

1704902..1706962

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057657.5 → NP_477005.1 capping protein beta, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477005.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48603, Q9VQ33

UniProtKB/TrEMBL

M9PBN7

Related

FBpp0077549

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit
NM_001272948.1 → NP_001259877.1 capping protein beta, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259877.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48603, Q9VQ33

UniProtKB/TrEMBL

M9PBN7

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit