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NLaz Neural Lazarillo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33324, updated on 4-Apr-2024

Summary

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Official Symbol
NLazprovided by FlyBase
Official Full Name
Neural Lazarilloprovided by FlyBase
Primary source
FLYBASE:FBgn0053126
Locus tag
Dmel_CG33126
See related
AllianceGenome:FB:FBgn0053126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE67583; CG16933; CG33126; CT33980; Dmel\CG33126; DNLaz; nlaz; Nlaz
Summary
Predicted to enable pigment binding activity. Involved in several processes, including carbohydrate homeostasis; determination of adult lifespan; and triglyceride homeostasis. Located in extracellular space. Is expressed in several structures, including aCC neuron; central nervous system; extended germ band embryo; gut; and ventral midline of embryo. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
22A1-22A1; 2-3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1359837..1361821, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1359837..1361821, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44898 Neighboring gene antisense RNA:CR44897 Neighboring gene roundabout 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo. Pasco MY, et al. PLoS One, 2012. PMID 22567167, Free PMC Article
  2. Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation. Ruiz M, et al. FEBS J, 2013 Aug. PMID 23777559
  3. Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. Ruiz M, et al. Insect Biochem Mol Biol, 2012 Oct. PMID 22846641
  4. Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. Ruiz M, et al. Exp Gerontol, 2011 Jul. PMID 21376794
  5. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Villanueva JE, et al. Nat Commun, 2019 Jun 20. PMID 31221967, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that NLazWT has stronger cell survival-promoting activity than NLazL130R under oxidative stress in a cell culture-based assay.
    Title: Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila.
  2. Data suggest that NLaz binds lyophilic ligands: retinoic acid, retinol, fatty acids, sphingomyelin, ergosterol, 7-tricosene. NLaz successfully delivers retinoic acid to immature neuronal cell line resulting in neurogenesis (i.e., neurite formation).
    Title: Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation.
  3. alters lifespan in both sexes
    Title: Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.
  4. NLaz is transcriptionally regulated by JNK signaling and is required for JNK-mediated stress.
    Title: Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables pigment binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to reactive oxygen species IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sexual reproduction HEP PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neural lazarillo
Names
CG33126-PA
CG33126-PB
CG33126-PC
NLaz-PA
NLaz-PB
NLaz-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1359837..1361821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298631.1 → NP_001285560.1  neural lazarillo, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285560.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXR1, Q9NAZ4, Q9VQ05
    Conserved Domains (1) summary
    cl21528
    Location:36 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_175946.2 → NP_787960.1  neural lazarillo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXR1, Q9NAZ4, Q9VQ05
    Related
    FBpp0077607
    Conserved Domains (1) summary
    cl21528
    Location:36 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  3. NM_001272938.2 → NP_001259867.1  neural lazarillo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBN2, Q9NAZ4
    Conserved Domains (1) summary
    cl21528
    Location:36 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBN2 M9PBN2
Q8SXR1 Q8SXR1
Q9NAZ4 Q9NAZ4

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