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Ldc1 leucine decarboxylase 1 [ Mus musculus (house mouse) ]

Gene ID: 332942, updated on 8-Feb-2024

Summary

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Official Symbol
Ldc1provided by MGI
Official Full Name
leucine decarboxylase 1provided by MGI
Primary source
MGI:MGI:2685699
See related
Ensembl:ENSMUSG00000023120 AllianceGenome:MGI:2685699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm853
Summary
Predicted to be involved in putrescine biosynthetic process from ornithine. Predicted to be active in cytoplasm. Orthologous to human LDC1P (leucine decarboxylase 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 23.2) See more
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Genomic context

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See Ldc1 in Genome Data Viewer
Location:
4 D2.2; 4 63.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130102816..130116221, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130209023..130222428, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40259 Neighboring gene tubulointerstitial nephritis antigen-like 1 Neighboring gene predicted gene, 52490 Neighboring gene predicted gene, 46724 Neighboring gene serine incorporator 2 Neighboring gene predicted gene, 34957

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney. Silander KM, et al. Biosci Rep, 2017 Aug 31. PMID 28607032, Free PMC Article
  2. The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase. Lambertos A, et al. Biochim Biophys Acta Gen Subj, 2018 Mar. PMID 29108956
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ornithine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in putrescine biosynthetic process from ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ornithine decarboxylase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034872.2 → NP_001030044.1  ornithine decarboxylase-like

    See identical proteins and their annotated locations for NP_001030044.1

    Status: VALIDATED

    Source sequence(s)
    AK143920
    Consensus CDS
    CCDS38890.1
    UniProtKB/TrEMBL
    A3KFW3, Q3UNZ2
    Related
    ENSMUSP00000023884.7, ENSMUST00000023884.7
    Conserved Domains (1) summary
    cd00622
    Location:50 → 410
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130102816..130116221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503200.4 → XP_006503263.1  ornithine decarboxylase-like isoform X6

    See identical proteins and their annotated locations for XP_006503263.1

    Conserved Domains (1) summary
    cl00261
    Location:1 → 150
    PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes

  2. XM_006503193.4 → XP_006503256.1  ornithine decarboxylase-like isoform X1

    See identical proteins and their annotated locations for XP_006503256.1

    Conserved Domains (1) summary
    cd00622
    Location:50 → 382
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

  3. XM_006503195.4 → XP_006503258.1  ornithine decarboxylase-like isoform X2

    See identical proteins and their annotated locations for XP_006503258.1

    Conserved Domains (1) summary
    cd00622
    Location:50 → 382
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

  4. XM_006503197.3 → XP_006503260.1  ornithine decarboxylase-like isoform X3

    See identical proteins and their annotated locations for XP_006503260.1

    UniProtKB/TrEMBL
    A3KFW3, Q3UNZ2
    Conserved Domains (1) summary
    cd00622
    Location:50 → 410
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

  5. XM_006503196.3 → XP_006503259.1  ornithine decarboxylase-like isoform X3

    See identical proteins and their annotated locations for XP_006503259.1

    UniProtKB/TrEMBL
    A3KFW3, Q3UNZ2
    Conserved Domains (1) summary
    cd00622
    Location:50 → 410
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

  6. XM_006503198.3 → XP_006503261.1  ornithine decarboxylase-like isoform X4

    See identical proteins and their annotated locations for XP_006503261.1

    UniProtKB/TrEMBL
    B7ZWH9
    Conserved Domains (1) summary
    cd00622
    Location:50 → 382
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

  7. XM_006503199.2 → XP_006503262.1  ornithine decarboxylase-like isoform X5

    See identical proteins and their annotated locations for XP_006503262.1

    Conserved Domains (1) summary
    cd00622
    Location:50 → 262
    PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
Nucleotide Protein Strain
Heading Accession and Version

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