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kraken [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33265, updated on 4-Apr-2024

Summary

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Official Symbol
krakenprovided by FlyBase
Primary source
FLYBASE:FBgn0020545
Locus tag
Dmel_CG3943
See related
AllianceGenome:FB:FBgn0020545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3943; Dmel\CG3943; Kra; Kraken; SERHL; SERHL2
Summary
Enables serine hydrolase activity. Involved in digestion and response to toxic substance. Is expressed in several structures, including embryonic head segment; embryonic main segment of Malpighian tubule; gut section; imaginal disc; and presumptive embryonic/larval system. Orthologous to several human genes including SERHL2 (serine hydrolase like 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
21E2-21E2; 2-1.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (852768..854539)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (852768..854539)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene drongo Neighboring gene long non-coding RNA:CR44060 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45345 Neighboring gene uncharacterized protein Neighboring gene mir-375 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. Fernández-Fúnez P, et al. EMBO J, 1998 Dec 1. PMID 9843490, Free PMC Article
  2. Identification and characterization of kraken, a gene encoding a putative hydrolytic enzyme in Drosophila melanogaster. Edwin Chan HY, et al. Gene, 1998 Nov 19. PMID 9831651
  3. Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genes. Keegan KP, et al. PLoS Comput Biol, 2007 Nov. PMID 17983263, Free PMC Article
  4. Molecular effects of dADD1 misexpression in chromatin organization and transcription. Meyer-Nava S, et al. BMC Mol Cell Biol, 2020 Mar 23. PMID 32293240, Free PMC Article
  5. Multiple-stress analysis for isolation of Drosophila longevity genes. Wang HD, et al. Proc Natl Acad Sci U S A, 2004 Aug 24. PMID 15308776, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in digestion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
kraken
Names
CG3943-PA
CG3943-PB
kraken-PA
kraken-PB
NP_001259847.1
NP_477265.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    852768..854539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057917.4 → NP_477265.1  kraken, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18391
    UniProtKB/TrEMBL
    M9PBM0
    Related
    FBpp0077681
    Conserved Domains (2) summary
    COG0596
    Location:61 → 329
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:63 → 159
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_001272918.1 → NP_001259847.1  kraken, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18391
    UniProtKB/TrEMBL
    M9PBM0
    Conserved Domains (2) summary
    COG0596
    Location:61 → 329
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:63 → 159
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBM0 M9PBM0
O18391.1 O18391

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