U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HSP90AA2P heat shock protein 90 alpha family class A member 2, pseudogene [ Homo sapiens (human) ]

Gene ID: 3324, updated on 10-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
HSP90AA2Pprovided by HGNC
Official Full Name
heat shock protein 90 alpha family class A member 2, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:5256
See related
MIM:140575; AllianceGenome:HGNC:5256
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPCA; HSPCAL3; HSP90AA2; HSP90ALPHA
Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HSP90AA2P in Genome Data Viewer
Location:
11p14.1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (27888171..27891092, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (28028805..28031726, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27909718..27912639, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:27743527-27744035 Neighboring gene uncharacterized LOC124902652 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27762065-27762756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27817576-27818442 Neighboring gene CBX3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4547 Neighboring gene uncharacterized LOC124902653 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:27955621-27956820 Neighboring gene uncharacterized LOC124902654

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Heat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study. Su K, et al. Hepatol Int, 2022 Oct. PMID 35972640, Free PMC Article
  2. Heat shock protein 90α in nipple discharge as a potential tumor marker for breast cancer. Wang YY, et al. Chin J Physiol, 2021 Sep-Oct. PMID 34708717
  3. Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study. Wang Y, et al. Oncol Res Treat, 2021. PMID 34547748
  4. Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer. Hou Q, et al. Int J Mol Sci, 2021 Jul 20. PMID 34299365, Free PMC Article
  5. Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma. Fan CS, et al. J Hematol Oncol, 2019 Dec 17. PMID 31847880, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition.
    Title: HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition.
  2. Extracellular Hsp90alpha stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.
    Title: Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.
  3. Heat-shock protein 90alpha is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.
    Title: Heat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.
  4. Value of HSP90alpha in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.
    Title: Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.
  5. Heat shock protein 90alpha in nipple discharge as a potential tumor marker for breast cancer.
    Title: Heat shock protein 90α in nipple discharge as a potential tumor marker for breast cancer.
  6. Extracellular Hsp90alpha Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
    Title: Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
  7. Modulation of Human Hsp90alpha Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain.
    Title: Modulation of Human Hsp90α Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain.
  8. High HSP90 alpha expression is associated with Endothelial-mesenchymal transition leading to exacerbate pancreatic ductal adenocarcinoma.
    Title: Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma.
  9. there was no difference in Hsp90alpha levels between overweight and obese children and healthy controls. Hsp90 isoforms had different expression in NAFLD patients. Also, Hsp90alpha levels were lower in overweight and obese NAFLD patients. However, Hsp90alpha to Hsp90beta ratio had better accuracy for NAFLD diagnosis in obese and overweight patients compared to individual biomarkers.
    Title: Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
  10. Study suggests that HSP90AA2 gene polymorphisms are associated with SLE susceptibility in Chinese population.
    Title: Associations of HSP90AA2 gene polymorphisms with disease susceptibility, glucocorticoids efficacy and health-related quality of life in Chinese systemic lupus erythematosus patients.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Other Names

  • heat shock 90kD protein, alpha-like 3
  • heat shock 90kDa protein 1, alpha-like 3
  • heat shock protein 86
  • heat shock protein 90kDa alpha (cytosolic), class A member 1 pseudogene
  • heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
  • heat shock protein 90kDa alpha family class A member 2, pseudogene

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005856.3 

    Range
    101..3022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    27888171..27891092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    28028805..28031726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040141.1: Suppressed sequence

    Description
    NM_001040141.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14568.2 GenPept UniProtKB/Swiss-Prot:Q14568

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.