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HSP90AA4P heat shock protein 90 alpha family class A member 4, pseudogene [ Homo sapiens (human) ]

Gene ID: 3323, updated on 3-Mar-2024

Summary

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Official Symbol
HSP90AA4Pprovided by HGNC
Official Full Name
heat shock protein 90 alpha family class A member 4, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:5255
See related
AllianceGenome:HGNC:5255
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP90Ad; HSPCAL2
Summary
Predicted to enable ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including myelin sheath; neuronal cell body; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
4q35.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (189472906..189475853)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (192829528..192832472)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (190394060..190397007)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900838 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:190229364-190230563 Neighboring gene uncharacterized LOC105377614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:190400698-190401256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:190405217-190405972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:190405973-190406728 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:190471799-190472998 Neighboring gene uncharacterized LOC105377615 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:190523074-190524273 Neighboring gene long intergenic non-protein coding RNA 1262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. Ozawa K, et al. Genomics, 1992 Feb. PMID 1740332
  2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. Chen B, et al. Genomics, 2005 Dec. PMID 16269234
  3. α-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation. Borutinskaite VV, et al. Mol Biol Rep, 2011 Jun. PMID 20111909
  4. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Beyer T, et al. Mol Cell Proteomics, 2018 Jul. PMID 29615496, Free PMC Article
  5. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Liu Y, et al. Cell Death Dis, 2019 Sep 9. PMID 31501420, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • heat shock 90kD protein 1, alpha-like 2
  • heat shock 90kDa protein 1, alpha-like 2
  • heat shock protein 90Ad
  • heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene
  • heat shock protein 90kDa alpha family class A member 4, pseudogene

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_003014.3 

    Range
    101..3048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    189472906..189475853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_187679.1 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    111049..113996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    192829528..192832472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_036692.1: Suppressed sequence

    Description
    NR_036692.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58FG1.1 GenPept UniProtKB/Swiss-Prot:Q58FG1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases