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cbt cabut [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33224, updated on 4-Apr-2024

Summary

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Official Symbol
cbtprovided by FlyBase
Official Full Name
cabutprovided by FlyBase
Primary source
FLYBASE:FBgn0043364
Locus tag
Dmel_CG4427
See related
AllianceGenome:FB:FBgn0043364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cabot; Cabut; Cbt; CG4427; Dmel\CG4427; dTIEG; EP(2)2237; EP2237
Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including dorsal closure; positive regulation of BMP signaling pathway; and wing disc development. Located in nucleus. Is expressed in several structures, including embryonic/larval garland cell; extended germ band embryo; germline cell; imaginal disc; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to several human genes including KLF11 (Kruppel like factor 11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
21D1-21D1; 2-1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (476446..479688, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (476446..479688, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 15 Neighboring gene u-shaped Neighboring gene long non-coding RNA:CR46258 Neighboring gene long non-coding RNA:CR46259

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hunting complex differential gene interaction patterns across molecular contexts. Song M, et al. Nucleic Acids Res, 2014 Apr. PMID 24482443, Free PMC Article
  2. Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins. Belacortu Y, et al. PLoS One, 2012. PMID 22359651, Free PMC Article
  3. Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster. Signor S, et al. Heredity (Edinb), 2018 Oct. PMID 30143789, Free PMC Article
  4. Cabut/dTIEG associates with the transcription factor Yorkie for growth control. Ruiz-Romero M, et al. EMBO Rep, 2015 Mar. PMID 25572844, Free PMC Article
  5. Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data. Hutchison AL, et al. PLoS Comput Biol, 2015 Mar. PMID 25793520, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.
    Title: A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.
  2. The Kruppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.
    Title: The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.
  3. Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.
    Title: Cabut/dTIEG associates with the transcription factor Yorkie for growth control.
  4. perturbation of CBT levels leads to deregulation of the circadian transcriptome and circadian behavioral patterns.
    Title: The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing.
  5. characterization of the molecular mechanisms of Cbt-mediated transcriptional control as well as of Cbt nuclear import
    Title: Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins.
  6. Cabut is localized on the surface of mitotic chromosomes at all mitotic phases
    Title: Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development.
  7. Cbt functions downstream of Jun regulating dpp expression in the leading edge cells during dorsal closure
    Title: Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in wing disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cabut
Names
CG4427-PA
CG4427-PB
CG4427-PC
TGF-beta-inducible early gene
cabot
cbt-PA
cbt-PB
cbt-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    476446..479688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164384.2 → NP_722636.1  cabut, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722636.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4R0P9, Q9VPQ5
    Related
    FBpp0077743
    Conserved Domains (4) summary
    COG5048
    Location:270 → 362
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:265 → 287
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:323 → 345
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:309 → 332
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001272903.1 → NP_001259832.1  cabut, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPV7, Q95R58
    Conserved Domains (4) summary
    COG5048
    Location:189 → 281
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 206
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:242 → 264
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:228 → 251
    zf-H2C2_2; Zinc-finger double domain

  3. NM_134685.3 → NP_608529.2  cabut, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608529.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPV7, Q95R58
    Related
    FBpp0077744
    Conserved Domains (4) summary
    COG5048
    Location:189 → 281
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 206
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:242 → 264
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:228 → 251
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4R0P9 Q4R0P9
Q8IPV7 Q8IPV7
Q95R58 Q95R58
Q9VPQ5 Q9VPQ5

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