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Zscan10 zinc finger and SCAN domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 332221, updated on 5-Mar-2024

Summary

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Official Symbol
Zscan10provided by MGI
Official Full Name
zinc finger and SCAN domain containing 10provided by MGI
Primary source
MGI:MGI:3040700
See related
Ensembl:ENSMUSG00000023902 AllianceGenome:MGI:3040700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp206; Znf206; Zkscan10
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; limb mesenchyme; and nervous system. Orthologous to human ZSCAN10 (zinc finger and SCAN domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.9), cerebellum adult (RPKM 0.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Zscan10 in Genome Data Viewer
Location:
17 A3.3; 17 11.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23819800..23829993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23600826..23611019)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330415G19 gene Neighboring gene STARR-positive B cell enhancer ABC_E9944 Neighboring gene zinc finger protein 213 Neighboring gene zinc finger protein 13 Neighboring gene STARR-seq mESC enhancer starr_42052 Neighboring gene STARR-seq mESC enhancer starr_42053 Neighboring gene STARR-seq mESC enhancer starr_42054 Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells. Yamane M, et al. Biochem Biophys Res Commun, 2015 Dec 25. PMID 26592664
  2. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Liang Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Apr 1. PMID 22505416, Free PMC Article
  3. Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin. Yanagihara Y, et al. Bone, 2019 May. PMID 30771488
  4. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Skamagki M, et al. Nat Cell Biol, 2017 Sep. PMID 28846095, Free PMC Article
  5. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206. Liang Y, et al. Nucleic Acids Res, 2012 Sep 1. PMID 22735705, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zscan10 negatively regulates osteoclast differentiation through transcription of Hp.
    Title: Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin.
  2. The pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes ROS-glutathione homeostasis and the DNA damage response, and recovers genomic stability.
    Title: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors.
  3. Our results clearly indicate that Zscan10 is dispensable for the ability of self-renewal and differentiation in ES cells.
    Title: Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells.
  4. a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof
    Title: Pleiotropic functions for transcription factor zscan10.
  5. Optimized crystals diffracted to 1.85 A resolution and belonged to space group I422, with unit-cell parameters a = 67.57, c = 87.54 A. A Matthews analysis indicated the presence of one Zfp206SCAN molecule per asymmetric unit
    Title: Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206.
  6. Zfp206 is a key component of the transcriptional regulatory network and together with Oct4 and Sox2 regulates differentiation of embryonic stem cells.
    Title: Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells.
  7. Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells.
    Title: Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells.
  8. Zfp206 is a regulator of embryonic stem cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators.
    Title: Zfp206 regulates ES cell gene expression and differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 10
Names
zinc finger and SCAN domains 10
zinc finger protein 206
zinc finger with KRAB and SCAN domains 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033425.4 → NP_001028597.2  zinc finger and SCAN domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001028597.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CF896527
    Consensus CDS
    CCDS28451.1
    UniProtKB/Swiss-Prot
    B7ZP53, Q20D61, Q20D62, Q20D63, Q3URR7
    Related
    ENSMUSP00000093255.3, ENSMUST00000095595.9
    Conserved Domains (6) summary
    cd07936
    Location:39 → 123
    SCAN; SCAN oligomerization domain
    COG5048
    Location:366 → 767
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:639 → 659
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:754 → 776
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:679 → 704
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:592 → 643
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  2. NM_001289481.1 → NP_001276410.1  zinc finger and SCAN domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001276410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in an isoform (2) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
    Consensus CDS
    CCDS70766.1
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000113386.2, ENSMUST00000120967.8
    Conserved Domains (6) summary
    cd07936
    Location:39 → 123
    SCAN; SCAN oligomerization domain
    COG5048
    Location:318 → 735
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:607 → 627
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:722 → 744
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:647 → 672
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:560 → 611
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  3. NM_001289482.1 → NP_001276411.1  zinc finger and SCAN domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. This results in an isoform (3) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CF896527
    Consensus CDS
    CCDS79510.1
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000111171.2, ENSMUST00000115509.8
    Conserved Domains (7) summary
    smart00431
    Location:39 → 147
    SCAN; leucine rich region
    cd07936
    Location:39 → 123
    SCAN; SCAN oligomerization domain
    COG5048
    Location:256 → 657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:644 → 666
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:569 → 594
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:482 → 533
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  4. NM_001289483.1 → NP_001276412.1  zinc finger and SCAN domain-containing protein 10 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate in-frame splice sites in the 5' and 3' coding region and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (4) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000118987.2, ENSMUST00000129227.8
    Conserved Domains (5) summary
    COG5048
    Location:114 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:403 → 423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:443 → 468
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:356 → 407
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  5. NM_001289484.1 → NP_001276413.1  zinc finger and SCAN domain-containing protein 10 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate in-frame splice sites in the 5' and 3' coding region, compared to variant 1. This results in an isoform (5) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000120876.2, ENSMUST00000148062.8
    Conserved Domains (6) summary
    cd07936
    Location:39 → 127
    SCAN; SCAN oligomerization domain
    COG5048
    Location:273 → 690
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:562 → 582
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:677 → 699
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:602 → 627
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:515 → 566
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23819800..23829993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URR7.2 GenPept UniProtKB/Swiss-Prot:Q3URR7

Gene LinkOut

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