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Zdhhc23 zinc finger, DHHC domain containing 23 [ Mus musculus (house mouse) ]

Gene ID: 332175, updated on 11-Apr-2024

Summary

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Official Symbol
Zdhhc23provided by MGI
Official Full Name
zinc finger, DHHC domain containing 23provided by MGI
Primary source
MGI:MGI:2685625
See related
Ensembl:ENSMUSG00000036304 AllianceGenome:MGI:2685625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nidd; Gm779; Gm1751; DHHC-23
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Acts upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including central nervous system; ileum; metanephros; reproductive system; and respiratory system. Orthologous to human ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 3.6), frontal lobe adult (RPKM 2.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 28.44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43785396..43800295, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43965033..43979820, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase accessory subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E1924 Neighboring gene predicted gene, 25989 Neighboring gene coiled-coil domain containing 191 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43951746-43952047 Neighboring gene predicted gene, 46552 Neighboring gene GRAM domain containing 1C Neighboring gene STARR-seq mESC enhancer starr_40889 Neighboring gene microRNA 3470b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. S-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits. Duncan PJ, et al. J Biol Chem, 2019 Aug 9. PMID 31213527, Free PMC Article
  2. In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation. Sadhukhan T, et al. J Inherit Metab Dis, 2021 Jul. PMID 33739454
  3. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
  4. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
  5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC23
Names
DHHC-containing protein 11
nNOS-intereacting DHHC-containing Dem protein-L
probable palmitoyltransferase ZDHHC23
zinc finger DHHC domain-containing protein 23
NP_001007461.1
NP_001355632.1
XP_006522374.1
XP_011244238.1
XP_017172544.1
XP_030105025.1
XP_030105026.1
XP_036015889.1
XP_036015890.1
XP_036015891.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007460.2 → NP_001007461.1  palmitoyltransferase ZDHHC23

    See identical proteins and their annotated locations for NP_001007461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC129306, CT025520
    Consensus CDS
    CCDS28180.1
    UniProtKB/Swiss-Prot
    A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 374
    DHHC; DHHC palmitoyltransferase

  2. NM_001368703.1 → NP_001355632.1  palmitoyltransferase ZDHHC23

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC129306, AK147553, CT025520
    Consensus CDS
    CCDS28180.1
    UniProtKB/Swiss-Prot
    A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
    Related
    ENSMUSP00000156253.2, ENSMUST00000231700.2
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 374
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    43785396..43800295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159996.1 → XP_036015889.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/Swiss-Prot
    A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
    Related
    ENSMUSP00000128650.2, ENSMUST00000165648.2
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 374
    DHHC; DHHC palmitoyltransferase

  2. XM_036159998.1 → XP_036015891.1  palmitoyltransferase ZDHHC23 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:210 → 336
    DHHC; DHHC palmitoyltransferase

  3. XM_036159997.1 → XP_036015890.1  palmitoyltransferase ZDHHC23 isoform X2

    UniProtKB/TrEMBL
    B7ZNY8
    Related
    ENSMUSP00000044744.8, ENSMUST00000036321.14
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 371
    DHHC; DHHC palmitoyltransferase

  4. XM_017317055.2 → XP_017172544.1  palmitoyltransferase ZDHHC23 isoform X1

    UniProtKB/Swiss-Prot
    A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 374
    DHHC; DHHC palmitoyltransferase

  5. XM_006522311.3 → XP_006522374.1  palmitoyltransferase ZDHHC23 isoform X1

    See identical proteins and their annotated locations for XP_006522374.1

    UniProtKB/Swiss-Prot
    A6H5Y4, Q3UH65, Q3UVA2, Q5Y5T3
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 374
    DHHC; DHHC palmitoyltransferase

  6. XM_011245936.2 → XP_011244238.1  palmitoyltransferase ZDHHC23 isoform X2

    See identical proteins and their annotated locations for XP_011244238.1

    UniProtKB/TrEMBL
    B7ZNY8
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 371
    DHHC; DHHC palmitoyltransferase

  7. XM_030249166.1 → XP_030105026.1  palmitoyltransferase ZDHHC23 isoform X3

    UniProtKB/TrEMBL
    B7ZNY9
    Related
    ENSMUSP00000156089.2, ENSMUST00000232055.2
    Conserved Domains (2) summary
    pfam01529
    Location:248 → 337
    DHHC; DHHC palmitoyltransferase
    pfam03203
    Location:90 → 155
    MerC; MerC mercury resistance protein

  8. XM_030249165.1 → XP_030105025.1  palmitoyltransferase ZDHHC23 isoform X2

    UniProtKB/TrEMBL
    B7ZNY8
    Conserved Domains (1) summary
    pfam01529
    Location:248 → 371
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5Y5T3.1 GenPept UniProtKB/Swiss-Prot:Q5Y5T3

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