U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Creld Cysteine rich with EGF like domains [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33166, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Creldprovided by FlyBase
Official Full Name
Cysteine rich with EGF like domainsprovided by FlyBase
Primary source
FLYBASE:FBgn0031217
Locus tag
Dmel_CG11377
See related
AllianceGenome:FB:FBgn0031217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11377; CT31762; Dmel\CG11377
Summary
Predicted to enable calcium ion binding activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to several human genes including CRELD1 (cysteine rich with EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
21B2-21B2; 2-0.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (102380..104142)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (102380..104142)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene net Neighboring gene Zizimin-related Neighboring gene Na[+]/H[+] hydrogen exchanger 1 Neighboring gene S-adenosylmethionine Synthetase Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Paradis M, et al. Sci Adv, 2022 Jul 22. PMID 35867795, Free PMC Article
  2. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
  3. Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family. Giannakou ME, et al. J Exp Biol, 2001 Nov. PMID 11719534
  4. A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions. Kolkhof P, et al. Mol Cell Proteomics, 2017 Mar. PMID 27956707, Free PMC Article
  5. SUMO-Enriched Proteome for Drosophila Innate Immune Response. Handu M, et al. G3 (Bethesda), 2015 Aug 18. PMID 26290570, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cysteine rich with EGF like domains
Names
CG11377-PA
CG11377-PB
Creld-PA
Creld-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    102380..104142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134646.4 → NP_608490.1  cysteine rich with EGF like domains, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPJ0
    Related
    FBpp0077763
    Conserved Domains (3) summary
    smart00179
    Location:231 → 259
    EGF_CA; Calcium-binding EGF-like domain
    smart00261
    Location:258 → 293
    FU; Furin-like repeats
    pfam11938
    Location:31 → 123
    DUF3456; TLR4 regulator and MIR-interacting MSAP

  2. NM_001272861.1 → NP_001259790.1  cysteine rich with EGF like domains, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDP6
    Conserved Domains (2) summary
    smart00261
    Location:258 → 292
    FU; Furin-like repeats
    pfam11938
    Location:31 → 123
    DUF3456; TLR4 regulator and MIR-interacting MSAP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDP6 M9PDP6
Q9VPJ0 Q9VPJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous