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Thoc2 THO complex 2 [ Mus musculus (house mouse) ]

Gene ID: 331401, updated on 5-Mar-2024

Summary

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Official Symbol
Thoc2provided by MGI
Official Full Name
THO complex 2provided by MGI
Primary source
MGI:MGI:2442413
See related
Ensembl:ENSMUSG00000037475 AllianceGenome:MGI:2442413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tho2; Gm1139; Gm1793; 6330441O12Rik; D130005M13Rik
Summary
Enables mRNA binding activity. Acts upstream of or within several processes, including blastocyst development; regulation of mRNA export from nucleus; and stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 9.1), whole brain E14.5 (RPKM 9.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Thoc2 in Genome Data Viewer
Location:
X A4; X 23.19 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (40883869..41000878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (41794992..41911937, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47054 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene mitogen-activated protein kinase associated protein 1 pseudogene Neighboring gene ribosomal protein S7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
  2. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
    Title: Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in generation of neurons ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
THO complex subunit 2
Names
transcription/export complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033422.1 → NP_001028594.1  THO complex subunit 2

    See identical proteins and their annotated locations for NP_001028594.1

    Status: VALIDATED

    Source sequence(s)
    AK031896, AK051141, AK138023, AK140950, CF423635, CN537042, CO045267, CX203600, CX213978
    Consensus CDS
    CCDS40951.1
    UniProtKB/Swiss-Prot
    B1AZI6
    Related
    ENSMUSP00000044677.9, ENSMUST00000047037.15
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:11 → 566
    THOC2_N; THO complex subunit 2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    40883869..41000878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541503.5 → XP_006541566.1  THO complex subunit 2 isoform X1

    Conserved Domains (4) summary
    TIGR01622
    Location:1475 → 1532
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:11 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  2. XM_036161990.1 → XP_036017883.1  THO complex subunit 2 isoform X2

    Conserved Domains (4) summary
    TIGR01622
    Location:1396 → 1453
    SF-CC1; splicing factor, CC1-like family
    pfam11262
    Location:795 → 1094
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:489 → 563
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:3 → 487
    THOC2_N; THO complex subunit 2 N-terminus

RNA

  1. XR_001782751.3 RNA Sequence

  2. XR_004940344.1 RNA Sequence

  3. XR_003953012.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AZI6.1 GenPept UniProtKB/Swiss-Prot:B1AZI6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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