HSPA7 heat shock protein family A (Hsp70) member 7 (pseudogene) [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSPA7provided by HGNC
Official Full Name: heat shock protein family A (Hsp70) member 7 (pseudogene)provided by HGNC
Primary source: HGNC:HGNC:5240
See related: Ensembl:ENSG00000225217 MIM:140556; AllianceGenome:HGNC:5240
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP70B
Summary: Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in blood microparticle and extracellular exosome. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 1q23.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (161606172..161608550)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (160950512..160952890)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (161575962..161578340)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA HSPA7 in human atherosclerotic plaques sponges miR-223 and promotes the proinflammatory vascular smooth muscle cell transition.
Title: LncRNA HSPA7 in human atherosclerotic plaques sponges miR-223 and promotes the proinflammatory vascular smooth muscle cell transition.
The N(6)-Methyladenosine-Modified Pseudogene HSPA7 Correlates With the Tumor Microenvironment and Predicts the Response to Immune Checkpoint Therapy in Glioblastoma.
Title: The N(6)-Methyladenosine-Modified Pseudogene HSPA7 Correlates With the Tumor Microenvironment and Predicts the Response to Immune Checkpoint Therapy in Glioblastoma.
Nutritional stresses, specifically the absence of glucose and glutamine, induced the HSP70B promoter, resulting in production of the downstream gene product.
Title: Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.
Celastrol induced expression of a wide set of Hsps, including Hsp70B', in differentiated human neurons grown in tissue culture.
Title: Induction of heat shock proteins in differentiated human and rodent neurons by celastrol.
Both Hsp70B' and Hsp72 are important for maintaining viability under conditions that increase the accumulation of damaged proteins in HT-29 cells.
Title: Hsp70B' regulation and function.
HSP70B expression is dependant on cell number and requires regulatory factors secreted by differentially secreted by cells at different stages of confluence.
Title: Cell number-dependent regulation of Hsp70B' expression: evidence of an extracellular regulator.
A highly sensitive detection method of cytoxicity was developed using a modified HSPA7 promoter.
Title: Highly sensitive detection of cytotoxicity using a modified HSP70B' promoter.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70826 (e-PCR)
- UniSTS:70149

STS-X51758 (e-PCR)
- UniSTS:44909

Other Names

heat shock 70kD protein 7 (HSP70B)
heat shock 70kDa protein 7 (HSP70B)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
located_in blood microparticle	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.