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Rnf150 ring finger protein 150 [ Mus musculus (house mouse) ]

Gene ID: 330812, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf150provided by MGI
Official Full Name
ring finger protein 150provided by MGI
Primary source
MGI:MGI:2443860
See related
Ensembl:ENSMUSG00000047747 AllianceGenome:MGI:2443860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Greul5; mKIAA1214; A630007N06Rik; C030044C12Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and spinal cord mantle layer. Orthologous to human RNF150 (ring finger protein 150). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 4.6), cortex adult (RPKM 4.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C2; 8 39.59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (83589889..83817900)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (82863266..83091271)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5023 Neighboring gene STARR-seq mESC enhancer starr_22070 Neighboring gene zinc finger protein 330 Neighboring gene predicted gene, 31545 Neighboring gene predicted gene, 46045 Neighboring gene STARR-seq mESC enhancer starr_22071 Neighboring gene zinc finger protein 235 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22072 Neighboring gene STARR-positive B cell enhancer mm9_chr8:85599639-85599939 Neighboring gene predicted gene, 53443 Neighboring gene STARR-positive B cell enhancer ABC_E6665 Neighboring gene STARR-seq mESC enhancer starr_22076 Neighboring gene TBC1 domain family, member 9 Neighboring gene predicted gene, 53444 Neighboring gene predicted gene, 42027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1214

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177378.4 → NP_796352.2  RING finger protein 150 precursor

    See identical proteins and their annotated locations for NP_796352.2

    Status: VALIDATED

    Source sequence(s)
    AC124757, AC132372, AC166939
    Consensus CDS
    CCDS40402.1
    UniProtKB/Swiss-Prot
    Q5DTZ6
    Related
    ENSMUSP00000077610.6, ENSMUST00000078525.7
    Conserved Domains (3) summary
    cd02122
    Location:45 → 192
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    pfam13639
    Location:275 → 318
    zf-RING_2; Ring finger domain
    cl11506
    Location:206 → 231
    UPF0233; uncharacterized protein family (UPF0233)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    83589889..83817900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154109.1 → XP_036010002.1  RING finger protein 150 isoform X4

    Conserved Domains (2) summary
    cd02122
    Location:45 → 192
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cl17238
    Location:289 → 313
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_017312865.3 → XP_017168354.1  RING finger protein 150 isoform X1

    Conserved Domains (2) summary
    cd02122
    Location:45 → 192
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16668
    Location:289 → 336
    RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family

  3. XM_017312866.3 → XP_017168355.1  RING finger protein 150 isoform X2

    Conserved Domains (2) summary
    cd02122
    Location:1 → 102
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16668
    Location:199 → 246
    RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family

  4. XM_030243623.2 → XP_030099483.1  RING finger protein 150 isoform X3

    Conserved Domains (3) summary
    cd02122
    Location:1 → 102
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cd16668
    Location:186 → 233
    RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family
    pfam13584
    Location:55 → 169
    BatD; Oxygen tolerance
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTZ6.2 GenPept UniProtKB/Swiss-Prot:Q5DTZ6

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