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Zfp866 zinc finger protein 866 [ Mus musculus (house mouse) ]

Gene ID: 330788, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp866provided by MGI
Official Full Name
zinc finger protein 866provided by MGI
Primary source
MGI:MGI:3584369
See related
Ensembl:ENSMUSG00000043090 AllianceGenome:MGI:3584369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830167H18Rik; D330038O06Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; heart; oocyte; sensory organ; and trunk somite. Orthologous to human ZNF670 (zinc finger protein 670) and ZNF844 (zinc finger protein 844). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.4), CNS E14 (RPKM 6.8) and 28 other tissues See more
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Genomic context

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Location:
8 B3.3; 8 33.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70213974..70227561, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69761324..69774911, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 963 Neighboring gene STARR-positive B cell enhancer ABC_E6642 Neighboring gene STARR-seq mESC enhancer starr_21745 Neighboring gene predicted gene, 19893 Neighboring gene STARR-positive B cell enhancer ABC_E6643 Neighboring gene STARR-positive B cell enhancer ABC_E6644 Neighboring gene ATPase type 13A1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:72332338-72332525 Neighboring gene Gem-interacting protein Neighboring gene predicted gene, 33695

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Potential readthrough

Included gene: Zfp963

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 866

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177899.3 → NP_808567.2  zinc finger protein 866

    See identical proteins and their annotated locations for NP_808567.2

    Status: VALIDATED

    Source sequence(s)
    AC157564, AK052363, AK137334, CO042014
    Consensus CDS
    CCDS40361.1
    UniProtKB/TrEMBL
    D3Z1K0, Q6PGD2
    Related
    ENSMUSP00000119781.2, ENSMUST00000137573.2
    Conserved Domains (5) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    COG5048
    Location:160 → 503
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164 → 184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:456 → 481
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70213974..70227561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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