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Htra4 HtrA serine peptidase 4 [ Mus musculus (house mouse) ]

Gene ID: 330723, updated on 11-Apr-2024

Summary

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Official Symbol
Htra4provided by MGI
Official Full Name
HtrA serine peptidase 4provided by MGI
Primary source
MGI:MGI:3036260
See related
Ensembl:ENSMUSG00000037406 AllianceGenome:MGI:3036260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B430206E18Rik
Summary
Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; lung; and muscle tissue. Orthologous to human HTRA4 (HtrA serine peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 3.8), lung adult (RPKM 1.2) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 13.7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25514944..25529160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25024928..25038962, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674 Neighboring gene TM2 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E6628 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11381 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:26213490-26213791 Neighboring gene STARR-seq mESC enhancer starr_20960 Neighboring gene STARR-positive B cell enhancer ABC_E8231 Neighboring gene STARR-positive B cell enhancer ABC_E11742 Neighboring gene STARR-positive B cell enhancer ABC_E6629 Neighboring gene STARR-seq mESC enhancer starr_20962 Neighboring gene STARR-seq mESC enhancer starr_20963 Neighboring gene predicted gene, 39143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and characterization of mice with a conditional null allele of the HtrA4 gene. Liu J, et al. Mol Med Rep, 2015 Nov. PMID 26353049, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease HTRA4
Names
high-temperature requirement factor A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081187.3 → NP_001074656.1  serine protease HTRA4 precursor

    See identical proteins and their annotated locations for NP_001074656.1

    Status: VALIDATED

    Source sequence(s)
    AK046614, AV315397, BB619816, BC145842
    Consensus CDS
    CCDS40301.1
    UniProtKB/Swiss-Prot
    A2RT60
    Related
    ENSMUSP00000081044.5, ENSMUST00000084031.6
    Conserved Domains (5) summary
    smart00280
    Location:121 → 140
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:145 → 479
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:386 → 477
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam00219
    Location:39 → 93
    IGFBP; Insulin-like growth factor binding protein
    pfam13365
    Location:208 → 346
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    25514944..25529160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154107.1 → XP_036010000.1  serine protease HTRA4 isoform X1

    Conserved Domains (3) summary
    TIGR02037
    Location:222 → 494
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam00219
    Location:85 → 139
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:156 → 204
    Kazal_2; Kazal-type serine protease inhibitor domain

  2. XM_036154108.1 → XP_036010001.1  serine protease HTRA4 isoform X2

    Conserved Domains (3) summary
    TIGR02037
    Location:222 → 476
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam00219
    Location:85 → 139
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:156 → 204
    Kazal_2; Kazal-type serine protease inhibitor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RT60.1 GenPept UniProtKB/Swiss-Prot:A2RT60

Gene LinkOut

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