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Trim66 tripartite motif-containing 66 [ Mus musculus (house mouse) ]

Gene ID: 330627, updated on 21-Apr-2024

Summary

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Official Symbol
Trim66provided by MGI
Official Full Name
tripartite motif-containing 66provided by MGI
Primary source
MGI:MGI:2152406
See related
Ensembl:ENSMUSG00000031026 AllianceGenome:MGI:2152406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tif1d; Kiaa0298-hp
Summary
Enables chromatin binding activity and identical protein binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in chromocenter and nucleus. Is expressed in olfactory epithelium. Orthologous to human TRIM66 (tripartite motif containing 66). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.6), cortex adult (RPKM 3.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.21 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109048208..109115948, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109449001..109516759, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 pseudogene Neighboring gene RIKEN cDNA 1700095J03 gene Neighboring gene STARR-seq mESC enhancer starr_19797 Neighboring gene predicted gene, 24888 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article
  2. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. Khetchoumian K, et al. J Biol Chem, 2004 Nov 12. PMID 15322135
  3. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. Amid C, et al. Cytogenet Cell Genet, 2001. PMID 11528127
  4. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Wajapeyee N, et al. Genes Dev, 2013 Oct 15. PMID 24105743, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest a role for transcriptional intermediary factor 1 (TIF1) delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis.
    Title: TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0298

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 66
Names
TIF1delta
transcriptional intermediary factor 1 delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170912.1 → NP_001164383.1  tripartite motif-containing protein 66 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC124457
    Consensus CDS
    CCDS52360.1
    UniProtKB/Swiss-Prot
    E9QLR8, Q5SEK4, Q5SEK5, Q924W6
    UniProtKB/TrEMBL
    B2RQQ4
    Related
    ENSMUSP00000102352.3, ENSMUST00000106741.10
    Conserved Domains (4) summary
    cd05502
    Location:1170 → 1278
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:210 → 335
    BBC; B-Box C-terminal domain
    pfam00643
    Location:166 → 201
    zf-B_box; B-box zinc finger
    cl22851
    Location:1097 → 1145
    PHD_SF; PHD finger superfamily

  2. NM_001170913.1 → NP_001164384.1  tripartite motif-containing protein 66 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124457, AK147559
    Consensus CDS
    CCDS52359.1
    UniProtKB/TrEMBL
    E9PZP2, Q3UH62
    Related
    ENSMUSP00000102350.2, ENSMUST00000106739.8
    Conserved Domains (4) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    pfam00643
    Location:64 → 99
    zf-B_box; B-box zinc finger
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

  3. NM_181853.4 → NP_862901.3  tripartite motif-containing protein 66 isoform 2

    See identical proteins and their annotated locations for NP_862901.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124457
    Consensus CDS
    CCDS40082.1
    UniProtKB/TrEMBL
    B2RQQ4
    Related
    ENSMUSP00000033339.7, ENSMUST00000033339.8
    Conserved Domains (8) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    pfam05109
    Location:548 → 782
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09770
    Location:293 → 449
    PAT1; Topoisomerase II-associated protein PAT1
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109048208..109115948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507959.2 → XP_006508022.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_006508022.1

    UniProtKB/TrEMBL
    B2RQQ4
    Conserved Domains (8) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    pfam05109
    Location:548 → 782
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09770
    Location:293 → 449
    PAT1; Topoisomerase II-associated protein PAT1
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

  2. XM_036153179.1 → XP_036009072.1  tripartite motif-containing protein 66 isoform X2

    UniProtKB/TrEMBL
    B2RQQ4
    Conserved Domains (5) summary
    cd05502
    Location:979 → 1087
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:19 → 144
    BBC; B-Box C-terminal domain
    PHA03369
    Location:293 → 525
    PHA03369; capsid maturational protease; Provisional
    PRK12757
    Location:419 → 510
    PRK12757; cell division protein FtsN; Provisional
    cd15625
    Location:906 → 954
    PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)

  3. XM_006507961.5 → XP_006508024.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_006508024.1

    UniProtKB/TrEMBL
    B2RQQ4
    Conserved Domains (8) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    pfam05109
    Location:548 → 782
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09770
    Location:293 → 449
    PAT1; Topoisomerase II-associated protein PAT1
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

  4. XM_011241835.4 → XP_011240137.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_011240137.1

    UniProtKB/TrEMBL
    B2RQQ4
    Conserved Domains (8) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    pfam05109
    Location:548 → 782
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09770
    Location:293 → 449
    PAT1; Topoisomerase II-associated protein PAT1
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

  5. XM_006507960.4 → XP_006508023.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_006508023.1

    UniProtKB/TrEMBL
    B2RQQ4
    Conserved Domains (8) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    pfam05109
    Location:548 → 782
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09770
    Location:293 → 449
    PAT1; Topoisomerase II-associated protein PAT1
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

  6. XM_006507962.2 → XP_006508025.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_006508025.1

    UniProtKB/TrEMBL
    B2RQQ4
    Conserved Domains (8) summary
    cd05502
    Location:1068 → 1176
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    pfam05109
    Location:548 → 782
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09770
    Location:293 → 449
    PAT1; Topoisomerase II-associated protein PAT1
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:995 → 1043
    PHD_SF; PHD finger superfamily

  7. XM_036153180.1 → XP_036009073.1  tripartite motif-containing protein 66 isoform X3

    Conserved Domains (4) summary
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    PHA03369
    Location:379 → 614
    PHA03369; capsid maturational protease; Provisional
    cd19794
    Location:63 → 105
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:4 → 40
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924W6.4 GenPept UniProtKB/Swiss-Prot:Q924W6

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