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Zfp82 zinc finger protein 82 [ Mus musculus (house mouse) ]

Gene ID: 330502, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp82provided by MGI
Official Full Name
zinc finger protein 82provided by MGI
Primary source
MGI:MGI:1890753
See related
Ensembl:ENSMUSG00000098022 AllianceGenome:MGI:1890753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mszf3; Krab16; Zfp-82; A030010D05
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZFP82 (ZFP82 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 1.3), CNS E18 (RPKM 1.2) and 23 other tissues See more
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Genomic context

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Location:
7 B1; 7 17.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29755459..29772248, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30056034..30072823, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18498 Neighboring gene zinc finger protein 568 Neighboring gene STARR-seq mESC enhancer starr_18501 Neighboring gene zinc finger protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E8161 Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869 Neighboring gene zinc finger protein 260

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice. Wang S, et al. Oncogene, 2021 Dec. PMID 34615997, Free PMC Article
  2. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  3. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  5. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice.
    Title: ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 82
Names
zinc finger protein 545

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252519.1 → NP_001239448.1  zinc finger protein 82 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    BC060530, BX525285, BY127198, CD806198
    Consensus CDS
    CCDS59723.1
    UniProtKB/TrEMBL
    S4R1G9
    Related
    ENSMUSP00000138217.2, ENSMUST00000182546.8
    Conserved Domains (5) summary
    smart00349
    Location:6 → 49
    KRAB; krueppel associated box
    COG5048
    Location:136 → 495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:308 → 328
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:321 → 345
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001253385.1 → NP_001240314.1  zinc finger protein 82 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct and significantly shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK037211, BY127198
    Consensus CDS
    CCDS59724.1
    UniProtKB/Swiss-Prot
    Q6P9Y7
    Related
    ENSMUSP00000138469.2, ENSMUST00000183190.2
    Conserved Domains (2) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    pfam01352
    Location:6 → 45
    KRAB; KRAB box

  3. NM_177889.5 → NP_808557.2  zinc finger protein 82 isoform 1

    See identical proteins and their annotated locations for NP_808557.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC060530, BX525285, BY127198
    Consensus CDS
    CCDS39876.1
    UniProtKB/Swiss-Prot
    Q6P9Y7, Q6ZPG0, Q8BIP1
    Related
    ENSMUSP00000079647.8, ENSMUST00000080834.15
    Conserved Domains (5) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:166 → 525
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338 → 358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:351 → 375
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29755459..29772248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9Y7.1 GenPept UniProtKB/Swiss-Prot:Q6P9Y7

Gene LinkOut

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