Cecr2 CECR2, histone acetyl-lysine reader [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cecr2provided by MGI
Official Full Name: CECR2, histone acetyl-lysine readerprovided by MGI
Primary source: MGI:MGI:1923799
See related: Ensembl:ENSMUSG00000071226 AllianceGenome:MGI:1923799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtl4; 2610101O16Rik; 2810409N01Rik
Summary: Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within inner ear development; primary neural tube formation; and single fertilization. Located in euchromatin. Part of ISWI-type complex. Is expressed in several structures, including extraembryonic component; genitourinary system; and olfactory epithelium. Used to study anencephaly. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 4.5), CNS E11.5 (RPKM 4.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 56.97 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (120643275..120748152)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (120666314..120771191)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CECR2 drives breast cancer metastasis by promoting NF-kappaB signaling and macrophage-mediated immune suppression.
Title: CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression.
Subfertility in young male mice mutant for chromatin remodeller CECR2.
Title: Subfertility in young male mice mutant for chromatin remodeller CECR2.
Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
Title: Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
Implantation failure and embryo loss contribute to subfertility in female mice mutant for chromatin remodeler Cecr2dagger.
Title: Implantation failure and embryo loss contribute to subfertility in female mice mutant for chromatin remodeler Cecr2†.
Cecr2 mutant mice as a model for human cat eye syndrome.
Title: Cecr2 mutant mice as a model for human cat eye syndrome.
The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure.
Title: The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure.
Reported DNA repair protein CECR2, which is associated with neural tube defects in mice, is not required for double-strand break repair in primary neurospheres.
Title: Reported DNA repair protein CECR2, which is associated with neural tube defects in mice, is not required for double-strand break repair in primary neurospheres.
Strain-specific modifier genes of Cecr2-associated exencephaly in mice.
Title: Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.
The results demonstrated a novel role of CECR2-containing complexes in spermatogenesis and showed that CECR2 interacts predominantly with SNF2H instead of SNF2L in the testis.
Title: CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.
Data show that two independent mutations of Cecr2 are also associated with specific inner ear defects.
Title: Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235544

D6Mit369 (e-PCR), detects polymorphism
- UniSTS:130923

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP-dependent chromatin remodeler activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural fold formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CERF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CERF complex	ISO Inferred from Sequence Orthology more info
part_of ISWI-type complex	IPI Inferred from Physical Interaction more info	PubMed
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromatin remodeling regulator CECR2

Names: cat eye syndrome chromosome region, candidate 2 homolog; cat eye syndrome critical region protein 2 homolog; gene trap locus 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128151.2 → NP_001121623.1 chromatin remodeling regulator CECR2 isoform 1

Status: VALIDATED

Source sequence(s)

AC084273, AC135105

Consensus CDS

CCDS51890.1

UniProtKB/Swiss-Prot

E9Q2Z1

Related

ENSMUSP00000108306.2, ENSMUST00000112686.8

Conserved Domains (2) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam15614
Location:244 → 284

WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
NM_001368706.1 → NP_001355635.1 chromatin remodeling regulator CECR2 isoform 2

Status: VALIDATED

Source sequence(s)

AC084273, AC135105

Consensus CDS

CCDS90117.1

UniProtKB/Swiss-Prot

E9Q2Z1, E9QA25, F6VR46, F7B218, Q6PAQ2, Q6ZPI9

Related

ENSMUSP00000098556.3, ENSMUST00000100993.9

Conserved Domains (2) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:558 → 1031

PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

120643275..120748152

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321659.3 → XP_017177148.1 chromatin remodeling regulator CECR2 isoform X1

Conserved Domains (2) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:558 → 1030

PHA03247; large tegument protein UL36; Provisional
XM_011241398.3 → XP_011239700.1 chromatin remodeling regulator CECR2 isoform X7

See identical proteins and their annotated locations for XP_011239700.1

Conserved Domains (1) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
XM_036166255.1 → XP_036022148.1 chromatin remodeling regulator CECR2 isoform X8

Conserved Domains (2) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

pfam03154
Location:567 → 740

Atrophin-1; Atrophin-1 family
XM_030255488.2 → XP_030111348.1 chromatin remodeling regulator CECR2 isoform X4

Conserved Domains (2) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:565 → 1002

PHA03247; large tegument protein UL36; Provisional
XM_036166256.1 → XP_036022149.1 chromatin remodeling regulator CECR2 isoform X9

Conserved Domains (1) summary

cd05509
Location:418 → 518

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
XM_011241396.3 → XP_011239698.1 chromatin remodeling regulator CECR2 isoform X2

See identical proteins and their annotated locations for XP_011239698.1

Conserved Domains (2) summary

cd05509
Location:390 → 490

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:530 → 1003

PHA03247; large tegument protein UL36; Provisional
XM_030255487.2 → XP_030111347.1 chromatin remodeling regulator CECR2 isoform X3

Conserved Domains (2) summary

cd05509
Location:390 → 490

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:530 → 1002

PHA03247; large tegument protein UL36; Provisional
XM_036166254.1 → XP_036022147.1 chromatin remodeling regulator CECR2 isoform X5

Conserved Domains (2) summary

cd05509
Location:390 → 490

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:537 → 975

PHA03247; large tegument protein UL36; Provisional
XM_011241397.3 → XP_011239699.1 chromatin remodeling regulator CECR2 isoform X6

See identical proteins and their annotated locations for XP_011239699.1

Conserved Domains (2) summary

cd05509
Location:277 → 377

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

PHA03247
Location:417 → 890

PHA03247; large tegument protein UL36; Provisional