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Tmcc1 transmembrane and coiled coil domains 1 [ Mus musculus (house mouse) ]

Gene ID: 330401, updated on 5-Mar-2024

Summary

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Official Symbol
Tmcc1provided by MGI
Official Full Name
transmembrane and coiled coil domains 1provided by MGI
Primary source
MGI:MGI:2442368
See related
Ensembl:ENSMUSG00000030126 AllianceGenome:MGI:2442368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0779; 3632431M01Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Predicted to be located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in nervous system and olfactory epithelium. Orthologous to human TMCC1 (transmembrane and coiled-coil domain family 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.3), whole brain E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115995572..116170485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116018611..116193521, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115921305-115921458 Neighboring gene plexin D1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115938993-115939194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115939698-115939944 Neighboring gene predicted gene, 53336 Neighboring gene STARR-positive B cell enhancer ABC_E3672 Neighboring gene STARR-positive B cell enhancer ABC_E6473 Neighboring gene RIKEN cDNA 9530062K07 gene Neighboring gene H2A histone family, member Z pseudogene Neighboring gene WASH complex subunit 2 Neighboring gene predicted gene, 52873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses. Jo D, et al. J Neuroinflammation, 2023 May 22. PMID 37217942, Free PMC Article
  2. In silico identification of new candidate genes for hereditary congenital facial paresis. Tomás-Roca L, et al. Int J Dev Neurosci, 2011 Jun. PMID 21345367
  3. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
  4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-kappaB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses.
    Title: Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome fission ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-endosome membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domains protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364577.1 → NP_001351506.1  transmembrane and coiled-coil domains protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK028322, AK036701, AK164892, BE983627
    Consensus CDS
    CCDS90105.1
    Related
    ENSMUSP00000133665.3, ENSMUST00000172510.4
    Conserved Domains (1) summary
    pfam10267
    Location:1 → 314
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. NM_177412.1 → NP_803131.1  transmembrane and coiled-coil domains protein 1 isoform 1

    See identical proteins and their annotated locations for NP_803131.1

    Status: VALIDATED

    Source sequence(s)
    AK173022, BY293575
    Consensus CDS
    CCDS51881.1
    UniProtKB/Swiss-Prot
    Q69ZZ6, Q8CEF4
    UniProtKB/TrEMBL
    Q8K2V2
    Related
    ENSMUSP00000086285.4, ENSMUST00000088896.10
    Conserved Domains (1) summary
    pfam10267
    Location:227 → 634
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115995572..116170485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166251.1 → XP_036022144.1  transmembrane and coiled-coil domains protein 1 isoform X6

    Conserved Domains (1) summary
    pfam10267
    Location:41 → 448
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. XM_006506309.3 → XP_006506372.1  transmembrane and coiled-coil domains protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10267
    Location:113 → 520
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  3. XM_006506308.4 → XP_006506371.1  transmembrane and coiled-coil domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006506371.1

    UniProtKB/Swiss-Prot
    Q69ZZ6, Q8CEF4
    UniProtKB/TrEMBL
    Q8K2V2
    Conserved Domains (1) summary
    pfam10267
    Location:227 → 634
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  4. XM_030255485.2 → XP_030111345.1  transmembrane and coiled-coil domains protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZZ6, Q8CEF4
    UniProtKB/TrEMBL
    Q8K2V2
    Conserved Domains (1) summary
    pfam10267
    Location:227 → 634
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  5. XM_036166253.1 → XP_036022146.1  transmembrane and coiled-coil domains protein 1 isoform X8

    UniProtKB/TrEMBL
    Q8K2V2
    Related
    ENSMUSP00000032222.10, ENSMUST00000032222.16
    Conserved Domains (1) summary
    pfam10267
    Location:271 → 678
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  6. XM_017321657.3 → XP_017177146.1  transmembrane and coiled-coil domains protein 1 isoform X7

    UniProtKB/Swiss-Prot
    Q69ZZ6
    Conserved Domains (1) summary
    pfam10267
    Location:1 → 314
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  7. XM_006506310.1 → XP_006506373.1  transmembrane and coiled-coil domains protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q69ZZ6
    Related
    ENSMUSP00000144971.2, ENSMUST00000204353.3
    Conserved Domains (1) summary
    pfam10267
    Location:52 → 459
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  8. XM_036166252.1 → XP_036022145.1  transmembrane and coiled-coil domains protein 1 isoform X7

    Conserved Domains (1) summary
    pfam10267
    Location:1 → 314
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  9. XM_006506312.4 → XP_006506375.1  transmembrane and coiled-coil domains protein 1 isoform X5

    Conserved Domains (1) summary
    pfam10267
    Location:47 → 454
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  10. XM_006506311.5 → XP_006506374.1  transmembrane and coiled-coil domains protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0N4SWB9
    Related
    ENSMUSP00000145456.2, ENSMUST00000173548.3
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 455
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZZ6.2 GenPept UniProtKB/Swiss-Prot:Q69ZZ6

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