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Gcfc2 GC-rich sequence DNA binding factor 2 [ Mus musculus (house mouse) ]

Gene ID: 330361, updated on 11-Apr-2024

Summary

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Official Symbol
Gcfc2provided by MGI
Official Full Name
GC-rich sequence DNA binding factor 2provided by MGI
Primary source
MGI:MGI:2141656
See related
Ensembl:ENSMUSG00000035125 AllianceGenome:MGI:2141656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCF2; Tcf9; A130099G21
Summary
Predicted to enable DNA binding activity. Predicted to be involved in spliceosomal complex assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of U2-type post-mRNA release spliceosomal complex. Predicted to be active in nucleus. Orthologous to human GCFC2 (GC-rich sequence DNA-binding factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.4), limb E14.5 (RPKM 4.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Gcfc2 in Genome Data Viewer
Location:
6 C3; 6 35.81 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (81887543..81936079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (81910562..81959098)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700009C05 gene Neighboring gene microRNA 7232 Neighboring gene microRNA 468 Neighboring gene STARR-positive B cell enhancer ABC_E9274 Neighboring gene mitochondrial ribosomal protein L19 Neighboring gene STARR-seq mESC enhancer starr_16423 Neighboring gene predicted gene, 38842 Neighboring gene predicted gene, 20383

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of GC binding factor 2 by RNA interference inhibits invasion and migration of vascular smooth muscle cells. Ma Y, et al. Mol Med Rep, 2019 Aug. PMID 31257544, Free PMC Article
  2. Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico. Maga AM, et al. Front Physiol, 2015. PMID 25859222, Free PMC Article
  3. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The inhibition of vascular smooth muscle cells proliferation and migration by knockdown of GCF2 by RNA interference was mediated by the PI3K/AKT signaling pathway.
    Title: Knockdown of GC binding factor 2 by RNA interference inhibits invasion and migration of vascular smooth muscle cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type post-mRNA release spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intron Large complex component GCFC2
Names
GCF
TCF-9
transcription factor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177884.4 → NP_808552.2  intron Large complex component GCFC2

    See identical proteins and their annotated locations for NP_808552.2

    Status: VALIDATED

    Source sequence(s)
    AC129024
    Consensus CDS
    CCDS20260.1
    UniProtKB/Swiss-Prot
    Q3UWF7, Q8BK44, Q8BKT3
    Related
    ENSMUSP00000035644.5, ENSMUST00000043195.11
    Conserved Domains (1) summary
    pfam07842
    Location:456 → 670
    GCFC; GC-rich sequence DNA-binding factor-like protein

RNA

  1. NR_177923.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129024

  2. NR_177924.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129024
    Related
    ENSMUST00000152996.8

  3. NR_177925.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129024

  4. NR_177926.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129024

  5. NR_177927.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129024

  6. NR_177928.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129024

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    81887543..81936079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255482.1 → XP_030111342.1  intron Large complex component GCFC2 isoform X1

    Conserved Domains (1) summary
    pfam07842
    Location:266 → 480
    GCFC; GC-rich sequence DNA-binding factor-like protein

  2. XM_030255483.2 → XP_030111343.1  intron Large complex component GCFC2 isoform X4

    UniProtKB/TrEMBL
    S4R198

  3. XM_011241391.1 → XP_011239693.1  intron Large complex component GCFC2 isoform X2

    Conserved Domains (1) summary
    pfam07842
    Location:253 → 467
    GCFC; GC-rich sequence DNA-binding factor-like protein

RNA

  1. XR_003956217.2 RNA Sequence

  2. XR_003956218.2 RNA Sequence

  3. XR_377475.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKT3.2 GenPept UniProtKB/Swiss-Prot:Q8BKT3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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