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Mindy4 MINDY lysine 48 deubiquitinase 4 [ Mus musculus (house mouse) ]

Gene ID: 330323, updated on 11-Apr-2024

Summary

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Official Symbol
Mindy4provided by MGI
Official Full Name
MINDY lysine 48 deubiquitinase 4provided by MGI
Primary source
MGI:MGI:3583959
See related
Ensembl:ENSMUSG00000038022 AllianceGenome:MGI:3583959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1406; Fam188b; C330043M08Rik
Summary
Predicted to enable Lys48-specific deubiquitinase activity. Predicted to act upstream of or within proteolysis. Orthologous to human MINDY4 (MINDY lysine 48 deubiquitinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 10.7), lung adult (RPKM 3.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 27.38 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55180337..55297208)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55203350..55320223)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15973 Neighboring gene predicted gene, 34358 Neighboring gene indolethylamine N-methyltransferase Neighboring gene predicted gene, 38819 Neighboring gene aquaporin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  2. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
probable ubiquitin carboxyl-terminal hydrolase MINDY-4
Names
family with sequence similarity 188, member B
probable deubiquitinating enzyme MINDY-4
probable ubiquitin carboxyl-terminal hydrolase FAM188B
protein FAM188B
NP_001136253.1
NP_808551.2
XP_006506359.1
XP_006506361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142781.1 → NP_001136253.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 1

    See identical proteins and their annotated locations for NP_001136253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK082855, AK142385
    Consensus CDS
    CCDS51782.1
    UniProtKB/Swiss-Prot
    Q3UQI9, Q8C472
    Related
    ENSMUSP00000061221.8, ENSMUST00000053094.8
    Conserved Domains (1) summary
    pfam13898
    Location:403 → 739
    DUF4205; Domain of unknown function (DUF4205)

  2. NM_177883.4 → NP_808551.2  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK082855, AK161304
    Consensus CDS
    CCDS85054.1
    UniProtKB/TrEMBL
    A0A0N4SVL4
    Related
    ENSMUSP00000145151.2, ENSMUST00000204842.3
    Conserved Domains (1) summary
    pfam13898
    Location:403 → 527
    DUF4205; Domain of unknown function (DUF4205)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55180337..55297208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506298.5 → XP_006506361.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X2

    UniProtKB/TrEMBL
    Q0VF82

  2. XM_006506296.4 → XP_006506359.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X1

    Conserved Domains (1) summary
    pfam13898
    Location:403 → 685
    DUF4205; Domain of unknown function (DUF4205)

RNA

  1. XR_004942977.1 RNA Sequence

  2. XR_003956212.2 RNA Sequence

  3. XR_004942976.1 RNA Sequence

  4. XR_003956211.2 RNA Sequence

  5. XR_003956214.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UQI9.1 GenPept UniProtKB/Swiss-Prot:Q3UQI9

Gene LinkOut

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