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Zfp786 zinc finger protein 786 [ Mus musculus (house mouse) ]

Gene ID: 330301, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp786provided by MGI
Official Full Name
zinc finger protein 786provided by MGI
Primary source
MGI:MGI:3026883
See related
Ensembl:ENSMUSG00000051499 AllianceGenome:MGI:3026883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf786; A730012O14Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus. Orthologous to human ZNF786 (zinc finger protein 786). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 1.8), CNS E18 (RPKM 1.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp786 in Genome Data Viewer
Location:
6 B2.3; 6 22.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47792470..47817061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47815536..47836197, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E438 Neighboring gene RNA, Y1 small cytoplasmic, Ro-associated Neighboring gene protein disulfide isomerase associated 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:47763598-47763839 Neighboring gene microRNA 704 Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_15785 Neighboring gene zinc finger protein 398 Neighboring gene zinc finger protein 282 Neighboring gene predicted gene, 52899 Neighboring gene Zinc finger protein 212

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 786

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177882.4 → NP_808550.1  zinc finger protein 786

    See identical proteins and their annotated locations for NP_808550.1

    Status: PROVISIONAL

    Source sequence(s)
    AC166252
    Consensus CDS
    CCDS20098.1
    UniProtKB/Swiss-Prot
    Q8BV42
    UniProtKB/TrEMBL
    B2RSK4
    Related
    ENSMUSP00000057495.6, ENSMUST00000058844.6
    Conserved Domains (5) summary
    smart00349
    Location:9 → 67
    KRAB; krueppel associated box
    COG5048
    Location:226 → 717
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:506 → 526
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:9 → 48
    KRAB; KRAB box
    pfam13465
    Location:658 → 680
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47792470..47817061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255477.2 → XP_030111337.1  zinc finger protein 786 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:113 → 171
    KRAB; krueppel associated box
    COG5048
    Location:330 → 821
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:610 → 630
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:346 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006506289.5 → XP_006506352.1  zinc finger protein 786 isoform X3

    See identical proteins and their annotated locations for XP_006506352.1

    Conserved Domains (4) summary
    COG5048
    Location:189 → 680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 30
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_030255479.2 → XP_030111339.1  zinc finger protein 786 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:189 → 680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 30
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. XM_030255478.1 → XP_030111338.1  zinc finger protein 786 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:189 → 680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 30
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. XM_006506288.3 → XP_006506351.1  zinc finger protein 786 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:28 → 86
    KRAB; krueppel associated box
    COG5048
    Location:245 → 736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:525 → 545
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BV42.1 GenPept UniProtKB/Swiss-Prot:Q8BV42

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