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Garin1b golgi associated RAB2 interactor 1B [ Mus musculus (house mouse) ]

Gene ID: 330277, updated on 5-Mar-2024

Summary

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Official Symbol
Garin1bprovided by MGI
Official Full Name
golgi associated RAB2 interactor 1Bprovided by MGI
Primary source
MGI:MGI:3032524
See related
Ensembl:ENSMUSG00000039742 AllianceGenome:MGI:3032524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm764; Fam71f1; GARI-L1; NYD-SP18
Summary
Orthologous to human FAM71F1 (family with sequence similarity 71 member F1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 95.0) See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29313468..29336021)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29313469..29336022)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4814 Neighboring gene hypoxia inducible lipid droplet associated Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene STARR-seq mESC enhancer starr_15437 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29297688-29297797 Neighboring gene calumenin Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Neighboring gene nuclear encoded tRNA proline 6 (anticodon AGG) Neighboring gene blue cone (S) opsin upstream regulatory region

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice. Morohoshi A, et al. Development, 2021 Nov 1. PMID 34714330, Free PMC Article
  2. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Fukuda M, et al. Mol Cell Proteomics, 2008 Jun. PMID 18256213
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.
    Title: FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC58790

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Golgi-associated RAB2 interactor protein 1B
Names
Golgi associated RAB2 interactor protein 1B
Golgi associated RAB2 interactor-like 1
Golgi-associated Rab2B interactor-like 1
family with sequence similarity 71, member F1
protein FAM71F1
testes development-related NYD-SP18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289663.1 → NP_001276592.1  Golgi-associated RAB2 interactor protein 1B isoform 1

    See identical proteins and their annotated locations for NP_001276592.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC044807, AK133908, BC172086
    Consensus CDS
    CCDS80497.1
    UniProtKB/TrEMBL
    B7ZWJ6
    Related
    ENSMUSP00000126496.2, ENSMUST00000164560.8
    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

  2. NM_001289664.1 → NP_001276593.1  Golgi-associated RAB2 interactor protein 1B isoform 2

    See identical proteins and their annotated locations for NP_001276593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC044807, AK133908, BC172074
    Consensus CDS
    CCDS80498.1
    UniProtKB/TrEMBL
    B7XG46
    Related
    ENSMUSP00000132703.2, ENSMUST00000166462.2
    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

  3. NM_001289665.1 → NP_001276594.1  Golgi-associated RAB2 interactor protein 1B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC044807, AK133908, BC172074
    UniProtKB/Swiss-Prot
    Q3UZD7
    UniProtKB/TrEMBL
    B7XG46
    Conserved Domains (1) summary
    pfam12480
    Location:111 → 176
    DUF3699; Protein of unknown function (DUF3699)

  4. NM_001411773.1 → NP_001398702.1  Golgi-associated RAB2 interactor protein 1B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC044807

  5. NM_001411774.1 → NP_001398703.1  Golgi-associated RAB2 interactor protein 1B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC044807

  6. NM_001411775.1 → NP_001398704.1  Golgi-associated RAB2 interactor protein 1B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC044807

  7. NM_207258.3 → NP_997141.2  Golgi-associated RAB2 interactor protein 1B isoform 3

    See identical proteins and their annotated locations for NP_997141.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC044807, AK133908
    Consensus CDS
    CCDS39451.1
    UniProtKB/Swiss-Prot
    B2RW23, Q3UZD7
    Related
    ENSMUSP00000087973.6, ENSMUST00000090487.12
    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29313468..29336021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255471.1 → XP_030111331.1  Golgi-associated RAB2 interactor protein 1B isoform X7

    Conserved Domains (1) summary
    pfam12480
    Location:111 → 176
    DUF3699; Protein of unknown function (DUF3699)

  2. XM_006505128.4 → XP_006505191.1  Golgi-associated RAB2 interactor protein 1B isoform X5

    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

  3. XM_017321651.1 → XP_017177140.1  Golgi-associated RAB2 interactor protein 1B isoform X1

    UniProtKB/TrEMBL
    B7ZWJ6
    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

  4. XM_017321652.1 → XP_017177141.1  Golgi-associated RAB2 interactor protein 1B isoform X2

    UniProtKB/TrEMBL
    B7XG46
    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

  5. XM_017321653.1 → XP_017177142.1  Golgi-associated RAB2 interactor protein 1B isoform X3

    UniProtKB/Swiss-Prot
    B2RW23, Q3UZD7
    Conserved Domains (1) summary
    pfam12480
    Location:143 → 208
    DUF3699; Protein of unknown function (DUF3699)

  6. XM_017321654.1 → XP_017177143.1  Golgi-associated RAB2 interactor protein 1B isoform X4

    Conserved Domains (1) summary
    pfam12480
    Location:111 → 176
    DUF3699; Protein of unknown function (DUF3699)

  7. XM_017321655.1 → XP_017177144.1  Golgi-associated RAB2 interactor protein 1B isoform X6

    Conserved Domains (1) summary
    pfam12480
    Location:54 → 116
    DUF3699; Protein of unknown function (DUF3699)

  8. XM_030255473.1 → XP_030111333.1  Golgi-associated RAB2 interactor protein 1B isoform X10

    Conserved Domains (1) summary
    pfam12480
    Location:54 → 116
    DUF3699; Protein of unknown function (DUF3699)

  9. XM_030255472.1 → XP_030111332.1  Golgi-associated RAB2 interactor protein 1B isoform X9

    Conserved Domains (1) summary
    pfam12480
    Location:111 → 176
    DUF3699; Protein of unknown function (DUF3699)

  10. XM_030255476.2 → XP_030111336.1  Golgi-associated RAB2 interactor protein 1B isoform X13

    Conserved Domains (1) summary
    pfam12480
    Location:111 → 176
    DUF3699; Protein of unknown function (DUF3699)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UZD7.1 GenPept UniProtKB/Swiss-Prot:Q3UZD7

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