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Ccdc63 coiled-coil domain containing 63 [ Mus musculus (house mouse) ]

Gene ID: 330188, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc63provided by MGI
Official Full Name
coiled-coil domain containing 63provided by MGI
Primary source
MGI:MGI:3607777
See related
Ensembl:ENSMUSG00000043036 AllianceGenome:MGI:3607777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921511C16Rik
Summary
Involved in spermatid development. Predicted to be active in axoneme. Orthologous to human CCDC63 (coiled-coil domain containing 63). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 46.0) See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 62.17 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122246115..122276143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122108052..122138080, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52785 Neighboring gene cut-like homeobox 2 Neighboring gene uncharacterized LOC118568726 Neighboring gene predicted gene, 52786 Neighboring gene VISTA enhancer mm77 Neighboring gene STARR-seq mESC enhancer starr_14271 Neighboring gene STARR-positive B cell enhancer ABC_E3613 Neighboring gene myosin, light polypeptide 2, regulatory, cardiac, slow Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595403-122595586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595588-122595697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122634438-122634667 Neighboring gene STARR-seq mESC enhancer starr_14277 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene STARR-positive B cell enhancer ABC_E9650 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122685188-122685492 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Young SA, et al. Int J Mol Sci, 2015 Oct 16. PMID 26501274, Free PMC Article
  2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289809.1 → NP_001276738.1  coiled-coil domain-containing protein 63 isoform 1

    See identical proteins and their annotated locations for NP_001276738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK029513, AV276792, AV278877, AV279232, AV280582, AV281915, BB614558
    UniProtKB/TrEMBL
    A7YTZ6

  2. NM_001289811.1 → NP_001276740.1  coiled-coil domain-containing protein 63 isoform 3

    See identical proteins and their annotated locations for NP_001276740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, initiates translation at a downstrean start codon and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC140353, AK029513, AV278877, AV281915, BB614558
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6

  3. NM_001384197.1 → NP_001371126.1  coiled-coil domain-containing protein 63 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140353
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6
    UniProtKB/TrEMBL
    D3YUZ2
    Conserved Domains (1) summary
    TIGR02168
    Location:148 → 422
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_001384198.1 → NP_001371127.1  coiled-coil domain-containing protein 63 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140353
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6
    Conserved Domains (1) summary
    TIGR02168
    Location:169 → 443
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. NM_001384199.1 → NP_001371128.1  coiled-coil domain-containing protein 63 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140353
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6
    UniProtKB/TrEMBL
    A0A0R4J0M8, D3YVN4
    Related
    ENSMUSP00000114311.3, ENSMUST00000132701.3
    Conserved Domains (1) summary
    TIGR02168
    Location:169 → 443
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. NM_001384200.1 → NP_001371129.1  coiled-coil domain-containing protein 63 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC140353
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6
    Conserved Domains (1) summary
    TIGR02168
    Location:148 → 422
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. NM_001384201.1 → NP_001371130.1  coiled-coil domain-containing protein 63 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140353
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6
    UniProtKB/TrEMBL
    D3YUZ2
    Related
    ENSMUSP00000114804.3, ENSMUST00000128101.9
    Conserved Domains (1) summary
    TIGR02168
    Location:148 → 422
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. NM_183307.4 → NP_899130.1  coiled-coil domain-containing protein 63 isoform 2

    See identical proteins and their annotated locations for NP_899130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region and uses an alternate splice site in the 3' terminal exon. This results in novel 3' coding region and novel 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK029513, AV278877, AV281915
    Consensus CDS
    CCDS39253.1
    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6
    UniProtKB/TrEMBL
    A0A0R4J0M8, D3YVN4
    Related
    ENSMUSP00000050582.8, ENSMUST00000058960.14
    Conserved Domains (1) summary
    TIGR02168
    Location:169 → 443
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122246115..122276143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248224.3 → XP_011246526.1  coiled-coil domain-containing protein 63 isoform X1

    See identical proteins and their annotated locations for XP_011246526.1

    UniProtKB/TrEMBL
    A7YTZ6
    Conserved Domains (1) summary
    COG1196
    Location:72 → 442
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_011248228.3 → XP_011246530.1  coiled-coil domain-containing protein 63 isoform X2

    See identical proteins and their annotated locations for XP_011246530.1

    UniProtKB/TrEMBL
    A7YTZ6
    Conserved Domains (1) summary
    COG1196
    Location:51 → 421
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_011248225.2 → XP_011246527.1  coiled-coil domain-containing protein 63 isoform X1

    See identical proteins and their annotated locations for XP_011246527.1

    UniProtKB/TrEMBL
    A7YTZ6
    Conserved Domains (1) summary
    COG1196
    Location:72 → 442
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_011248227.3 → XP_011246529.1  coiled-coil domain-containing protein 63 isoform X2

    See identical proteins and their annotated locations for XP_011246529.1

    UniProtKB/TrEMBL
    A7YTZ6
    Conserved Domains (1) summary
    COG1196
    Location:51 → 421
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_011248229.3 → XP_011246531.1  coiled-coil domain-containing protein 63 isoform X3

    UniProtKB/Swiss-Prot
    Q0VF78, Q8CDV6

  6. XM_011248222.3 → XP_011246524.1  coiled-coil domain-containing protein 63 isoform X1

    See identical proteins and their annotated locations for XP_011246524.1

    UniProtKB/TrEMBL
    A7YTZ6
    Conserved Domains (1) summary
    COG1196
    Location:72 → 442
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_011248223.4 → XP_011246525.1  coiled-coil domain-containing protein 63 isoform X1

    See identical proteins and their annotated locations for XP_011246525.1

    UniProtKB/TrEMBL
    A7YTZ6
    Conserved Domains (1) summary
    COG1196
    Location:72 → 442
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_006530389.5 → XP_006530452.1  coiled-coil domain-containing protein 63 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDV6.2 GenPept UniProtKB/Swiss-Prot:Q8CDV6

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