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Taok3 TAO kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 330177, updated on 11-Apr-2024

Summary

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Official Symbol
Taok3provided by MGI
Official Full Name
TAO kinase 3provided by MGI
Primary source
MGI:MGI:3041177
See related
Ensembl:ENSMUSG00000061288 AllianceGenome:MGI:3041177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A130052D22; 2900006A08Rik; A430105I05Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; protein autophosphorylation; and regulation of MAPK cascade. Predicted to act upstream of or within DNA repair and phosphorylation. Predicted to be active in cytoplasm. Is expressed in renal vasculature. Orthologous to human TAOK3 (TAO kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 7.8), liver E14.5 (RPKM 6.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 56.88 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117258180..117413283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117120111..117275101)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42011 Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene predicted gene 3786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity. Maes B, et al. J Exp Med, 2023 Sep 4. PMID 37347461, Free PMC Article
  2. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Li Z, et al. Biochem Biophys Res Commun, 2020 Oct 22. PMID 32807497, Free PMC Article
  3. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Hammad H, et al. Nat Immunol, 2017 Mar. PMID 28068307
  4. The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice. Maes B, et al. J Allergy Clin Immunol, 2022 Apr. PMID 34506849
  5. TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells. Vanderkerken M, et al. Proc Natl Acad Sci U S A, 2020 Dec 8. PMID 33214146, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
    Title: The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
  2. Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.
    Title: Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.
  3. STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.
    Title: STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.
  4. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
    Title: TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
  5. this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10
    Title: Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (7)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase TAO3
Names
thousand and one amino acid protein 3
NP_001074777.1
NP_001186614.1
NP_899129.2
XP_006530448.1
XP_011246521.1
XP_011246522.1
XP_011246523.1
XP_030110461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081308.2 → NP_001074777.1  serine/threonine-protein kinase TAO3

    See identical proteins and their annotated locations for NP_001074777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different segment and lacks an alternate exon in its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA182196, AC110234, AK042181, BM225493, BY201674, CK625948
    Consensus CDS
    CCDS39233.1
    UniProtKB/Swiss-Prot
    Q3V3B3, Q8BYC6
    UniProtKB/TrEMBL
    B2RY27
    Related
    ENSMUSP00000090565.6, ENSMUST00000092889.12
    Conserved Domains (2) summary
    PTZ00121
    Location:415 → 881
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:2 → 314
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001199685.1 → NP_001186614.1  serine/threonine-protein kinase TAO3

    See identical proteins and their annotated locations for NP_001186614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA182196, AC110234, AK040531, AK042181, BC158072
    Consensus CDS
    CCDS39233.1
    UniProtKB/Swiss-Prot
    Q3V3B3, Q8BYC6
    UniProtKB/TrEMBL
    B2RY27
    Related
    ENSMUSP00000107609.2, ENSMUST00000111978.8
    Conserved Domains (2) summary
    PTZ00121
    Location:415 → 881
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:2 → 314
    PKc_like; Protein Kinases, catalytic domain

  3. NM_183306.2 → NP_899129.2  serine/threonine-protein kinase TAO3

    See identical proteins and their annotated locations for NP_899129.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA182196, AC110234, AK042181, BM225493, BY201674, CK625948
    Consensus CDS
    CCDS39233.1
    UniProtKB/Swiss-Prot
    Q3V3B3, Q8BYC6
    UniProtKB/TrEMBL
    B2RY27
    Related
    ENSMUSP00000136750.2, ENSMUST00000179276.8
    Conserved Domains (2) summary
    PTZ00121
    Location:415 → 881
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:2 → 314
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    117258180..117413283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530385.5 → XP_006530448.1  serine/threonine-protein kinase TAO3 isoform X1

    See identical proteins and their annotated locations for XP_006530448.1

    UniProtKB/Swiss-Prot
    Q3V3B3, Q8BYC6
    UniProtKB/TrEMBL
    B2RY27
    Conserved Domains (2) summary
    PTZ00121
    Location:415 → 881
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:2 → 314
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011248219.4 → XP_011246521.1  serine/threonine-protein kinase TAO3 isoform X1

    See identical proteins and their annotated locations for XP_011246521.1

    UniProtKB/Swiss-Prot
    Q3V3B3, Q8BYC6
    UniProtKB/TrEMBL
    B2RY27
    Conserved Domains (2) summary
    PTZ00121
    Location:415 → 881
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:2 → 314
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011248220.4 → XP_011246522.1  serine/threonine-protein kinase TAO3 isoform X1

    See identical proteins and their annotated locations for XP_011246522.1

    UniProtKB/Swiss-Prot
    Q3V3B3, Q8BYC6
    UniProtKB/TrEMBL
    B2RY27
    Conserved Domains (2) summary
    PTZ00121
    Location:415 → 881
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:2 → 314
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011248221.4 → XP_011246523.1  serine/threonine-protein kinase TAO3 isoform X2

    UniProtKB/TrEMBL
    B2RY27
    Conserved Domains (2) summary
    PTZ00121
    Location:245 → 711
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:1 → 144
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030254601.2 → XP_030110461.1  serine/threonine-protein kinase TAO3 isoform X2

    UniProtKB/TrEMBL
    B2RY27
    Conserved Domains (2) summary
    PTZ00121
    Location:245 → 711
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:1 → 144
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYC6.2 GenPept UniProtKB/Swiss-Prot:Q8BYC6

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