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Kctd10 potassium channel tetramerisation domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 330171, updated on 21-Apr-2024

Summary

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Official Symbol
Kctd10provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 10provided by MGI
Primary source
MGI:MGI:2141207
See related
Ensembl:ENSMUSG00000001098 AllianceGenome:MGI:2141207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mBACURD3
Summary
Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within angiogenesis; heart development; and negative regulation of Notch signaling pathway. Part of MKS complex. Is expressed in clavicle; mandible; maxilla; midgut; and rib. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 118.3), colon adult (RPKM 56.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114501633..114518566, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114363572..114380505, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase beta Neighboring gene STARR-seq mESC enhancer starr_14069 Neighboring gene STARR-seq mESC enhancer starr_14070 Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene STARR-positive B cell enhancer mm9_chr5:114762243-114762544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114765155-114765411 Neighboring gene myosin 1H Neighboring gene ubiquitin protein ligase E3B Neighboring gene microRNA 7027 Neighboring gene STARR-positive B cell enhancer ABC_E278 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling. Ye MS, et al. J Endocrinol, 2022 Jan 13. PMID 34854382
  2. Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape? Navarro N, et al. G3 (Bethesda), 2016 May 3. PMID 26921296, Free PMC Article
  3. KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. Ren K, et al. PLoS One, 2014. PMID 25401743, Free PMC Article
  4. A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Chih B, et al. Nat Cell Biol, 2011 Dec 18. PMID 22179047
  5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.
    Title: KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.
  2. KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.
    Title: KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.
  3. Our studies suggest that KCTD10 plays crucial roles in embryonic angiogenesis and heart development in mammalians by negatively regulating the Notch signaling pathway.
    Title: KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11654

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MKS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MKS complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Names
BTB/POZ domain-containing protein KCTD10
potassium channel tetramerization domain-containing 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159941.1 → NP_001153413.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147714, AK161199, BB855690, BQ571808
    Consensus CDS
    CCDS51623.1
    UniProtKB/TrEMBL
    F8WGQ9
    Related
    ENSMUSP00000001125.6, ENSMUST00000001125.6
    Conserved Domains (2) summary
    smart00225
    Location:33 → 131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:34 → 124
    BTB_2; BTB/POZ domain

  2. NM_026145.4 → NP_080421.2  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2

    See identical proteins and their annotated locations for NP_080421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK147714, AK161199, BB855690
    Consensus CDS
    CCDS19563.1
    UniProtKB/Swiss-Prot
    Q922M3
    Related
    ENSMUSP00000099641.5, ENSMUST00000102581.11
    Conserved Domains (2) summary
    smart00225
    Location:33 → 131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:34 → 124
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114501633..114518566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922M3.1 GenPept UniProtKB/Swiss-Prot:Q922M3

Gene LinkOut

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