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Catsper4 cation channel, sperm associated 4 [ Mus musculus (house mouse) ]

Gene ID: 329954, updated on 5-Mar-2024

Summary

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Official Symbol
Catsper4provided by MGI
Official Full Name
cation channel, sperm associated 4provided by MGI
Primary source
MGI:MGI:3043288
See related
Ensembl:ENSMUSG00000048003 AllianceGenome:MGI:3043288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933412L05
Summary
Enables voltage-gated calcium channel activity. Acts upstream of or within flagellated sperm motility; sodium ion transport; and sperm capacitation. Located in acrosomal vesicle and sperm principal piece. Part of CatSper complex. Orthologous to human CATSPER4 (cation channel sperm associated 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 45.5) See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 66.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133939276..133954743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134211965..134227431, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 Neighboring gene STARR-positive B cell enhancer mm9_chr4:133715471-133715771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133742713-133742822 Neighboring gene STARR-positive B cell enhancer ABC_E843 Neighboring gene zona pellucida like domain containing 2 Neighboring gene connector enhancer of kinase suppressor of Ras 1 Neighboring gene STARR-positive B cell enhancer ABC_E7997 Neighboring gene Zfp593 opposite strand Neighboring gene zinc finger protein 593

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Jin J, et al. Biol Reprod, 2007 Jul. PMID 17344468
  2. CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model. Rezaian J, et al. Spinal Cord, 2009 Jan. PMID 18607386
  3. CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Xia J, et al. Biol Reprod, 2007 Sep. PMID 17554080
  4. Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis. Jin JL, et al. Biol Reprod, 2005 Dec. PMID 16107607
  5. Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. Lobley A, et al. Reprod Biol Endocrinol, 2003 Aug 1. PMID 12932298, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that spinal cord injury doesn't significantly change the expression of CatSpers 4.
    Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
  2. Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
    Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
  3. Catsper4 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
    Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
  4. CATSPER4 is a cation-channel protein and has role in acrosome reaction and male fertility
    Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124305, MGC124306

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-activated cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sperm capacitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cation channel sperm-associated protein 4
Names
cation channel of sperm 4
channel, sperm associated 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130030.1 → NP_001123502.1  cation channel sperm-associated protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001123502.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing 2 contiguous internal coding exons compared to variant 1, however, it maintains the reading frame, and encodes a shorter isoform (2) that is lacking a 73 aa internal segment compared to isoform 1.
    Source sequence(s)
    AK077145, BY104668, CR513858, EU781511
    Consensus CDS
    CCDS51324.1
    UniProtKB/TrEMBL
    B3VNK5
    Related
    ENSMUSP00000131094.2, ENSMUST00000169381.8
    Conserved Domains (2) summary
    pfam00520
    Location:126 → 216
    Ion_trans; Ion transport protein
    cl00567
    Location:101 → 201
    Colicin_V; Colicin V production protein

  2. NM_177866.4 → NP_808534.1  cation channel sperm-associated protein 4 isoform 1

    See identical proteins and their annotated locations for NP_808534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK077145, BY104668, CR513858
    Consensus CDS
    CCDS18766.1
    UniProtKB/Swiss-Prot
    A2A9K6, Q8BVN3
    Related
    ENSMUSP00000051694.4, ENSMUST00000055892.10
    Conserved Domains (1) summary
    pfam00520
    Location:81 → 289
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133939276..133954743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164199.1 → XP_036020092.1  cation channel sperm-associated protein 4 isoform X1

    Conserved Domains (1) summary
    pfam00520
    Location:81 → 289
    Ion_trans; Ion transport protein

  2. XM_011250280.3 → XP_011248582.1  cation channel sperm-associated protein 4 isoform X2

    Conserved Domains (1) summary
    pfam00520
    Location:81 → 243
    Ion_trans; Ion transport protein

RNA

  1. XR_004941926.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVN3.1 GenPept UniProtKB/Swiss-Prot:Q8BVN3

Gene LinkOut

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