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Csmd2 CUB and Sushi multiple domains 2 [ Mus musculus (house mouse) ]

Gene ID: 329942, updated on 11-Apr-2024

Summary

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Official Symbol
Csmd2provided by MGI
Official Full Name
CUB and Sushi multiple domains 2provided by MGI
Primary source
MGI:MGI:2386401
See related
Ensembl:ENSMUSG00000028804 AllianceGenome:MGI:2386401
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm139
Summary
Is expressed in central nervous system and ganglia. Orthologous to human CSMD2 (CUB and Sushi multiple domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.4), whole brain E14.5 (RPKM 3.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 61.65 cM
Exon count:
72
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (127880310..128461459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (127986505..128567660)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11449 Neighboring gene predicted gene, 40256 Neighboring gene cDNA sequence CK137956 Neighboring gene predicted gene, 38571 Neighboring gene STARR-seq mESC enhancer starr_11450 Neighboring gene STARR-seq mESC enhancer starr_11451 Neighboring gene STARR-seq mESC enhancer starr_11452 Neighboring gene high-mobility group box 4, opposite strand Neighboring gene high-mobility group box 4 Neighboring gene STARR-seq mESC enhancer starr_11453 Neighboring gene predicted gene, 33656 Neighboring gene STARR-positive B cell enhancer ABC_E839 Neighboring gene zinc finger and SCAN domains 20 Neighboring gene toll-like receptor 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation. Gutierrez MA, et al. eNeuro, 2019 Mar/Apr. PMID 31068362, Free PMC Article
  2. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Csmd2 plays a role in development and maintenance of dendrites and synapses.
    Title: Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1884, B230311I21, B230378I17

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in maintenance of postsynaptic density structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of postsynaptic density structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic density assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
CUB and sushi domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281955.1 → NP_001268884.1  CUB and sushi domain-containing protein 2

    Status: PROVISIONAL

    Source sequence(s)
    AL611934, AL611969, AL627093, AL807807, AL928698, AL954639
    Consensus CDS
    CCDS84795.1
    UniProtKB/TrEMBL
    V9GX34
    Related
    ENSMUSP00000138958.3, ENSMUST00000184063.3
    Conserved Domains (6) summary
    cd00033
    Location:3136 → 3189
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:184 → 241
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:2658 → 2894
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:623 → 730
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:2297 → 2354
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:1490 → 1595
    CUB; CUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    127880310..128461459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240560.4 → XP_011238862.1  CUB and sushi domain-containing protein 2 isoform X1

    Conserved Domains (6) summary
    cd00033
    Location:2959 → 3012
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:184 → 241
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:2658 → 2894
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:623 → 730
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:2297 → 2354
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:1490 → 1595
    CUB; CUB domain

  2. XM_036164198.1 → XP_036020091.1  CUB and sushi domain-containing protein 2 isoform X2

    Conserved Domains (5) summary
    cd00033
    Location:566 → 620
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:184 → 241
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd00041
    Location:623 → 730
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:2126 → 2181
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:1490 → 1595
    CUB; CUB domain

RNA

  1. XR_001784158.3 RNA Sequence

  2. XR_001784159.3 RNA Sequence

  3. XR_001784160.3 RNA Sequence

  4. XR_867884.4 RNA Sequence

  5. XR_003954975.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033413.1: Suppressed sequence

    Description
    NM_001033413.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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