Acot11 acyl-CoA thioesterase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot11provided by MGI
Official Full Name: acyl-CoA thioesterase 11provided by MGI
Primary source: MGI:MGI:1913736
See related: Ensembl:ENSMUSG00000034853 AllianceGenome:MGI:1913736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BFIT; Thea; BFIT1; Them1; mKIAA0707; 1110020M10Rik; 2010309H15Rik
Summary: Predicted to enable long-chain acyl-CoA hydrolase activity; long-chain fatty acyl-CoA binding activity; and palmitoyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within response to cold. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol. Orthologous to human ACOT11 (acyl-CoA thioesterase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in small intestine adult (RPKM 28.1), large intestine adult (RPKM 26.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 49.75 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (106601752..106662204, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (106744555..106805007, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.
Title: Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.
The liver-specific Them1 expression did not influence glucose tolerance or insulin sensitivity, but did promote hepatic gluconeogenesis in high-fat-fed animals.
Title: Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1.
BFIT supports the transition of thermogenic brown adipose tissue towards increased metabolic activity, probably through alteration of intracellular fatty acyl-CoA concentration.
Title: BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	TAS Traceable Author Statement more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to temperature stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 11

Names: acyl-CoA thioester hydrolase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; palmitoyl-coenzyme A thioesterase; thioesterase, adipose associated

NP_001334088.1

EC 3.1.2.2

NP_079866.2

EC 3.1.2.2

XP_011238858.1

EC 3.1.2.2

XP_036020090.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347159.1 → NP_001334088.1 acyl-coenzyme A thioesterase 11 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

AL929585

Consensus CDS

CCDS84764.1

UniProtKB/TrEMBL

A2AVR6, Q80TT9

Related

ENSMUSP00000069636.7, ENSMUST00000065253.13
NM_025590.4 → NP_079866.2 acyl-coenzyme A thioesterase 11 isoform 2

See identical proteins and their annotated locations for NP_079866.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to variant 1.

Source sequence(s)

AK048670, AL929585

Consensus CDS

CCDS18426.1

UniProtKB/Swiss-Prot

Q8VHQ9

UniProtKB/TrEMBL

Q543P6, Q80TT9

Related

ENSMUSP00000099823.4, ENSMUST00000102762.10

Conserved Domains (2) summary

cd03442
Location:214 → 337

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

cl14643
Location:345 → 583

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

106601752..106662204 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240556.2 → XP_011238858.1 acyl-coenzyme A thioesterase 11 isoform X1

See identical proteins and their annotated locations for XP_011238858.1

UniProtKB/TrEMBL

Q80TT9, Q8CAL6

Conserved Domains (2) summary

cd03442
Location:199 → 322

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

cl14643
Location:330 → 568

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036164197.1 → XP_036020090.1 acyl-coenzyme A thioesterase 11 isoform X2

UniProtKB/TrEMBL

Q80TT9

Conserved Domains (3) summary

cd03442
Location:90 → 213

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

cl00509
Location:1 → 66

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

cl14643
Location:221 → 459

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily