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Usp24 ubiquitin specific peptidase 24 [ Mus musculus (house mouse) ]

Gene ID: 329908, updated on 21-Apr-2024

Summary

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Official Symbol
Usp24provided by MGI
Official Full Name
ubiquitin specific peptidase 24provided by MGI
Primary source
MGI:MGI:1919936
See related
Ensembl:ENSMUSG00000028514 AllianceGenome:MGI:1919936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130021E18; 2700066K03Rik; 2810030C21Rik
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol and nucleus. Is expressed in olfactory cortex. Orthologous to human USP24 (ubiquitin specific peptidase 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 8.3), thymus adult (RPKM 7.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C7; 4 49.44 cM
Exon count:
71
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106173179..106303798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106315980..106446613)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54246 Neighboring gene STARR-seq mESC enhancer starr_10989 Neighboring gene predicted gene 12724 Neighboring gene STARR-seq mESC enhancer starr_10992 Neighboring gene predicted gene, 40218 Neighboring gene proprotein convertase subtilisin/kexin type 9 Neighboring gene predicted gene, 30487 Neighboring gene barttin CLCNK type accessory beta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. Bedekovics T, et al. Cancer Res, 2021 Mar 1. PMID 33355202
  2. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Jahan AS, et al. Proc Natl Acad Sci U S A, 2016 Feb 9. PMID 26811477, Free PMC Article
  3. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
  4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of NF-kappaB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.
    Title: Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.
  2. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
    Title: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 24
Names
deubiquitinating enzyme 24
ubiquitin specific protease 24
ubiquitin thioesterase 24
ubiquitin thiolesterase 24
ubiquitin-specific-processing protease 24
NP_899048.2
XP_006503239.1
XP_006503240.1
XP_006503241.1
XP_006503243.1
XP_036020087.1
XP_036020089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183225.2 → NP_899048.2  ubiquitin carboxyl-terminal hydrolase 24

    See identical proteins and their annotated locations for NP_899048.2

    Status: VALIDATED

    Source sequence(s)
    AL840623, AL954352
    Consensus CDS
    CCDS51251.1
    UniProtKB/Swiss-Prot
    B1AY13, Q8BLI7
    UniProtKB/TrEMBL
    E9PV45
    Conserved Domains (3) summary
    cd02659
    Location:1684 → 2041
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14286
    Location:6 → 42
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    pfam00443
    Location:1686 → 2036
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    106173179..106303798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503180.5 → XP_006503243.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

    Conserved Domains (2) summary
    cd14286
    Location:6 → 42
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    cd17065
    Location:972 → 1050
    Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

  2. XM_036164196.1 → XP_036020089.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

    Conserved Domains (3) summary
    cd14286
    Location:6 → 42
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    cd17065
    Location:972 → 1050
    Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    cl02553
    Location:1704 → 1865
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  3. XM_006503177.5 → XP_006503240.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

    UniProtKB/TrEMBL
    E9PV45
    Conserved Domains (3) summary
    cd02659
    Location:1704 → 2061
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14286
    Location:6 → 42
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    cd17065
    Location:972 → 1050
    Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

  4. XM_006503176.5 → XP_006503239.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

    UniProtKB/TrEMBL
    E9PV45
    Related
    ENSMUSP00000092538.6, ENSMUST00000094933.6
    Conserved Domains (3) summary
    cd02659
    Location:1704 → 2061
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14286
    Location:6 → 42
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    cd17065
    Location:972 → 1050
    Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

  5. XM_036164194.1 → XP_036020087.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

    UniProtKB/TrEMBL
    E9PV45
    Conserved Domains (2) summary
    cd02659
    Location:1532 → 1889
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd17065
    Location:800 → 878
    Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

  6. XM_006503178.4 → XP_006503241.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

    Conserved Domains (2) summary
    cd02659
    Location:1092 → 1449
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd17065
    Location:360 → 438
    Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AY13.1 GenPept UniProtKB/Swiss-Prot:B1AY13

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