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HSF4 heat shock transcription factor 4 [ Homo sapiens (human) ]

Gene ID: 3299, updated on 10-Mar-2024

Summary

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Official Symbol
HSF4provided by HGNC
Official Full Name
heat shock transcription factor 4provided by HGNC
Primary source
HGNC:HGNC:5227
See related
Ensembl:ENSG00000102878 MIM:602438; AllianceGenome:HGNC:5227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTM; CTRCT5
Summary
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
16q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67163761..67169941)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72958053..72964234)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67197664..67203844)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phagosome assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7581 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene TNFRSF1A associated via death domain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67209861-67210290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67211873-67212416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67212417-67212958 Neighboring gene nucleolar protein 3 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel mutations in HSF4 cause congenital cataracts in Chinese families. Cao Z, et al. BMC Med Genet, 2018 Aug 24. PMID 30143024, Free PMC Article
  2. A novel missense mutation in HSF4 causes autosomal-dominant congenital lamellar cataract in a British family. Berry V, et al. Eye (Lond), 2018 Apr. PMID 29243736, Free PMC Article
  3. High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. Yang Y, et al. IUBMB Life, 2017 Dec. PMID 29131521
  4. A novel homozygous mutation in HSF4 causing autosomal recessive congenital cataract. Behnam M, et al. J Hum Genet, 2016 Feb. PMID 26490182
  5. A novel HSF4 mutation in a Chinese family with autosomal dominant congenital cataract. Liu L, et al. J Huazhong Univ Sci Technolog Med Sci, 2015 Apr. PMID 25877371

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-330-5p Suppress Cell Growth and Invasion via Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer.
    Title: miR-330-5p Suppress Cell Growth and Invasion via Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer.
  2. Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts.
    Title: Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts.
  3. The results expand the spectrum of HSF4 mutations causing congenital cataracts.
    Title: Novel mutations in HSF4 cause congenital cataracts in Chinese families.
  4. Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha B-crystallin proteins expression, while knocking down UAP56 by shRNA reversed it.
    Title: Heat shock factor 4 regulates the expression of HSP25 and alpha B-crystallin by associating with DEXD/H-box RNA helicase UAP56.
  5. We have identified a novel mutation in HSF4 in a large British pedigree causing dominant congenital lamellar cataract
    Title: A novel missense mutation in HSF4 causes autosomal-dominant congenital lamellar cataract in a British family.
  6. High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer.
    Title: High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer.
  7. In the cultured human lens epithelial cells, HSF4 could stabilize and retain p53 in the nucleus to activate its target genes such as fas cell surface death receptor (Fas) and Bcl-2-associated X apoptosis regulator (Bax).
    Title: HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
  8. HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation.
    Title: HSF4 transcriptional regulates HMOX-1 expression in HLECs.
  9. report on a novel homozygous HSF4 mutation (c.521T>C, p.Leu174Pro) in two sibs with congenital cataracts
    Title: A novel homozygous mutation in HSF4 causing autosomal recessive congenital cataract.
  10. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
    Title: BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cataract 5 multiple types
MedGen: C0266537 OMIM: 116800 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock factor protein 4
Names
HSF 4
HSTF 4
hHSF4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009294.1 RefSeqGene

    Range
    6361..11557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040667.3 → NP_001035757.1  heat shock factor protein 4 isoform b

    See identical proteins and their annotated locations for NP_001035757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform b). This variant, alternatively referred to as HSF4b, functions as a transcriptional activator of the constitutive expression of heat shock genes.
    Source sequence(s)
    AC074143, AK307211, BC130383, BX348481, CA412687
    Consensus CDS
    CCDS42175.1
    UniProtKB/Swiss-Prot
    Q99472, Q9ULV5, Q9ULV6
    UniProtKB/TrEMBL
    E5RK26
    Conserved Domains (3) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    pfam06546
    Location:259 → 443
    Vert_HS_TF; Vertebrate heat shock transcription factor
    pfam15035
    Location:110 → 175
    Rootletin; Ciliary rootlet component, centrosome cohesion

  2. NM_001374674.1 → NP_001361603.1  heat shock factor protein 4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AK225152, AK293631, D87673
    Consensus CDS
    CCDS45510.1
    UniProtKB/TrEMBL
    E5RK26
    Related
    ENSP00000463706.1, ENST00000584272.5
    Conserved Domains (2) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    pfam15035
    Location:110 → 175
    Rootletin; Ciliary rootlet component, centrosome cohesion

  3. NM_001374675.1 → NP_001361604.1  heat shock factor protein 4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AB029348, AC074143, AK293631, D87673
    Consensus CDS
    CCDS42175.1
    UniProtKB/Swiss-Prot
    Q99472, Q9ULV5, Q9ULV6
    UniProtKB/TrEMBL
    E5RK26
    Related
    ENSP00000430947.2, ENST00000521374.6
    Conserved Domains (3) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    pfam06546
    Location:259 → 443
    Vert_HS_TF; Vertebrate heat shock transcription factor
    pfam15035
    Location:110 → 175
    Rootletin; Ciliary rootlet component, centrosome cohesion

  4. NM_001538.4 → NP_001529.2  heat shock factor protein 4 isoform a

    See identical proteins and their annotated locations for NP_001529.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter protein (isoform a). This variant, alternatively referred to as HSF4a, functions as an inhibitor of the constitutive expression of heat shock genes.
    Source sequence(s)
    AK307211, BX348481, CA412687, D87673
    Consensus CDS
    CCDS45510.1
    UniProtKB/TrEMBL
    E5RK26
    Conserved Domains (2) summary
    smart00415
    Location:16 → 120
    HSF; heat shock factor
    pfam15035
    Location:110 → 175
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67163761..67169941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72958053..72964234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULV5.2 GenPept UniProtKB/Swiss-Prot:Q9ULV5

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