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Dennd4c DENN domain containing 4C [ Mus musculus (house mouse) ]

Gene ID: 329877, updated on 11-Apr-2024

Summary

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Official Symbol
Dennd4cprovided by MGI
Official Full Name
DENN domain containing 4Cprovided by MGI
Primary source
MGI:MGI:1914769
See related
Ensembl:ENSMUSG00000038024 AllianceGenome:MGI:1914769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700065A05Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in cellular response to insulin stimulus and protein localization to plasma membrane. Located in cytosol; insulin-responsive compartment; and plasma membrane. Part of retromer complex. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.8), subcutaneous fat pad adult (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C4; 4 40.69 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86666761..86768841)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86748518..86850603)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10694 Neighboring gene perilipin 2 pseudogene Neighboring gene perilipin 2 Neighboring gene STARR-seq mESC enhancer starr_10695 Neighboring gene STARR-seq mESC enhancer starr_10697 Neighboring gene STARR-seq mESC enhancer starr_10698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:86358735-86358844 Neighboring gene predicted gene, 42312 Neighboring gene STARR-positive B cell enhancer ABC_E7973 Neighboring gene predicted gene 6521 Neighboring gene STARR-seq mESC enhancer starr_10700 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10701 Neighboring gene STARR-positive B cell enhancer ABC_E11244 Neighboring gene ribosomal protein S6 Neighboring gene STARR-seq mESC enhancer starr_10704 Neighboring gene STARR-seq mESC enhancer starr_10705 Neighboring gene alkaline ceramidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. Borner GH, et al. J Cell Biol, 2012 Apr 2. PMID 22472443, Free PMC Article
  2. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. Sano H, et al. J Biol Chem, 2011 May 13. PMID 21454697, Free PMC Article
  3. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C
    Title: Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in insulin-responsive compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of retromer complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DENN domain-containing protein 4C
Names
DENN/MADD domain containing 4C
likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405424.1 → NP_001392353.1  DENN domain-containing protein 4C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772228, BX005084
    Related
    ENSMUSP00000080685.7, ENSMUST00000082026.14

  2. NM_001405425.1 → NP_001392354.1  DENN domain-containing protein 4C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL772228, BX005084
    UniProtKB/Swiss-Prot
    A2AJX5, A6H8H2, Q3U2K9

  3. NM_184088.2 → NP_908976.1  DENN domain-containing protein 4C isoform 1

    See identical proteins and their annotated locations for NP_908976.1

    Status: VALIDATED

    Source sequence(s)
    AL772228, BX005084
    Consensus CDS
    CCDS51218.2
    UniProtKB/Swiss-Prot
    A2AJX5, A6H8H2, Q3U2K9
    UniProtKB/TrEMBL
    E9Q449
    Related
    ENSMUSP00000123367.3, ENSMUST00000142837.3
    Conserved Domains (4) summary
    smart00801
    Location:558 → 631
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 275
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:819 → 848
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:308 → 491
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    86666761..86768841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538023.4 → XP_006538086.1  DENN domain-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_006538086.1

    UniProtKB/TrEMBL
    E9Q449
    Related
    ENSMUSP00000039860.9, ENSMUST00000045512.15
    Conserved Domains (4) summary
    smart00801
    Location:558 → 631
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:192 → 275
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:819 → 848
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:308 → 491
    DENN; DENN (AEX-3) domain

  2. XM_006538024.4 → XP_006538087.1  DENN domain-containing protein 4C isoform X3

    Conserved Domains (4) summary
    smart00801
    Location:323 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:584 → 613
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:73 → 256
    DENN; DENN (AEX-3) domain
    cl04085
    Location:1 → 40
    uDENN; uDENN domain

  3. XM_006538025.4 → XP_006538088.1  DENN domain-containing protein 4C isoform X4

RNA

  1. XR_390327.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081014.1: Suppressed sequence

    Description
    NM_001081014.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H8H2.1 GenPept UniProtKB/Swiss-Prot:A6H8H2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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