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Pigk phosphatidylinositol glycan anchor biosynthesis, class K [ Mus musculus (house mouse) ]

Gene ID: 329777, updated on 11-Apr-2024

Summary

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Official Symbol
Pigkprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Kprovided by MGI
Primary source
MGI:MGI:1913863
See related
Ensembl:ENSMUSG00000039047 AllianceGenome:MGI:1913863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG-K; Gm38470; 3000001O05Rik
Summary
Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein and protein localization to cell surface. Predicted to act upstream of or within GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of GPI-anchor transamidase complex. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.3), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pigk in Genome Data Viewer
Location:
3; 3 H3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152419718..152548705)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152714085..152842926)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 5 Neighboring gene expressed sequence AI115009 Neighboring gene STARR-seq mESC enhancer starr_09298 Neighboring gene STARR-positive B cell enhancer ABC_E9232 Neighboring gene predicted gene, 32085 Neighboring gene STARR-positive B cell enhancer ABC_E6147 Neighboring gene predicted gene, 40181 Neighboring gene ribosomal protein L29, pseudogene 1 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene STARR-positive B cell enhancer ABC_E3479 Neighboring gene predicted gene, 46830 Neighboring gene STARR-seq mESC enhancer starr_09299 Neighboring gene predicted gene, 40182

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination. Boutlis CS, et al. Curr Top Microbiol Immunol, 2005. PMID 16265905
  2. The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase. Yu J, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356492, Free PMC Article
  3. Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. Eisenhaber B, et al. Bioessays, 2003 Apr. PMID 12655644
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protein encoded by the human ortholog catalyzes the final step in glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins, the transamidation reaction.
    Title: The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GPI-anchor transamidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GPI-anchor transamidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI-anchor transamidase
Names
GPI transamidase
phosphatidylinositol-glycan biosynthesis class K protein
NP_079938.1
NP_821135.1
XP_006501675.1
XP_036019035.1
XP_036019036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025662.5 → NP_079938.1  GPI-anchor transamidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_079938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 2.
    Source sequence(s)
    AK077893, BC060175
    Consensus CDS
    CCDS17919.1
    UniProtKB/Swiss-Prot
    Q8BH63, Q9CXY9
    UniProtKB/TrEMBL
    E9Q421
    Related
    ENSMUSP00000123772.2, ENSMUST00000159899.8
    Conserved Domains (1) summary
    cl00042
    Location:42 → 332
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. NM_178016.3 → NP_821135.1  GPI-anchor transamidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_821135.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK046246, AK077893, BC060175
    Consensus CDS
    CCDS17920.1
    UniProtKB/TrEMBL
    E9Q421, Q8BL63
    Related
    ENSMUSP00000045351.9, ENSMUST00000045029.15
    Conserved Domains (1) summary
    cl00042
    Location:42 → 379
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    152419718..152548705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163142.1 → XP_036019035.1  GPI-anchor transamidase isoform X1

    UniProtKB/TrEMBL
    E9Q421, Q8BXX3
    Related
    ENSMUSP00000123899.2, ENSMUST00000162642.8
    Conserved Domains (1) summary
    cl00042
    Location:42 → 332
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_036163143.1 → XP_036019036.1  GPI-anchor transamidase isoform X2

    UniProtKB/TrEMBL
    E9Q421
    Related
    ENSMUSP00000123753.2, ENSMUST00000161596.6
    Conserved Domains (1) summary
    cl00042
    Location:42 → 332
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  3. XM_006501612.5 → XP_006501675.1  GPI-anchor transamidase isoform X3

    Conserved Domains (1) summary
    cl00042
    Location:1 → 248
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RNA

  1. XR_004941347.1 RNA Sequence

  2. XR_004941339.1 RNA Sequence

  3. XR_004941341.1 RNA Sequence

  4. XR_003954342.2 RNA Sequence

  5. XR_004941344.1 RNA Sequence

  6. XR_004941343.1 RNA Sequence

  7. XR_004941346.1 RNA Sequence

  8. XR_004941338.1 RNA Sequence

  9. XR_004941345.1 RNA Sequence

  10. XR_004941342.1 RNA Sequence

  11. XR_004941340.1 RNA Sequence

  12. XR_003954341.2 RNA Sequence

  13. XR_004941348.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXY9.2 GenPept UniProtKB/Swiss-Prot:Q9CXY9

Gene LinkOut

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