Bpi bactericidal permeablility increasing protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpiprovided by MGI
Official Full Name: bactericidal permeablility increasing proteinprovided by MGI
Primary source: MGI:MGI:3045315
See related: Ensembl:ENSMUSG00000052922 AllianceGenome:MGI:3045315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bpifd1; 9230105K17Rik
Summary: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of macrophage activation; and response to bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in Crohn's disease. Orthologous to human BPI (bactericidal permeability increasing protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 29.4) and testis adult (RPKM 24.9) See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 78.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (158099983..158126453)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (158258063..158284533)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis.
Title: Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis.
Bactericidal Permeability Increasing Protein Deficiency Aggravates Acute Colitis in Mice by Increasing the Serum Levels of Lipopolysaccharide.
Title: Bactericidal Permeability Increasing Protein Deficiency Aggravates Acute Colitis in Mice by Increasing the Serum Levels of Lipopolysaccharide.
Findings suggest that residue Asp190 combined with surrounding positively charged residues largely contribute to bactericidal and endotoxin-neutralizing activities of bactericidal/permeability-increasing protein (BPI) mBPI5.
Title: Importance of the residue 190 on bactericidal activity of the bactericidal/permeability-increasing protein 5.
Data suggest that BPI is expressed in testis and epididymis (but not in seminal vesicles, prostate, or solidification glands); BPI expression in epididymis is up-regulated by testosterone; BPI may participate in process of sperm-oocyte interaction.
Title: Bactericidal/permeability-increasing protein in the reproductive system of male mice may be involved in the sperm-oocyte fusion.
data demonstrate that murine BPI is a potent LPS-neutralizing protein that may limit innate immune responses during Gram-negative infections
Title: Murine bactericidal/permeability-increasing protein inhibits the endotoxic activity of lipopolysaccharide and gram-negative bacteria.
The mouse neutrophils store BPI with antibacterial activity and that murine BPI is also expressed in testis and epididymis.
Title: A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow.
the requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo.
Title: Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bactericidal permeability-increasing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356542.1 → NP_001343471.1 bactericidal permeability-increasing protein isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AY648037

Consensus CDS

CCDS89574.1

UniProtKB/Swiss-Prot

A2AC63, Q5I5I4, Q67E05, Q8BSF3

Related

ENSMUSP00000105125.2, ENSMUST00000109499.8

Conserved Domains (2) summary

smart00328
Location:36 → 259

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:244 → 482

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
NM_177850.3 → NP_808518.1 bactericidal permeability-increasing protein isoform 1 precursor

See identical proteins and their annotated locations for NP_808518.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK033770

Consensus CDS

CCDS16987.1

UniProtKB/Swiss-Prot

Q67E05

Related

ENSMUSP00000067837.3, ENSMUST00000065039.3

Conserved Domains (2) summary

smart00328
Location:36 → 259

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:244 → 485

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

158099983..158126453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319055.1 → XP_017174544.1 bactericidal permeability-increasing protein isoform X1

Related

ENSMUSP00000105126.2, ENSMUST00000109500.8

Conserved Domains (2) summary

smart00328
Location:86 → 309

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:294 → 531

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
XM_017319056.2 → XP_017174545.1 bactericidal permeability-increasing protein isoform X2

Conserved Domains (2) summary

smart00328
Location:34 → 211

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:196 → 434

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...