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Nol4l nucleolar protein 4-like [ Mus musculus (house mouse) ]

Gene ID: 329540, updated on 18-Apr-2024

Summary

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Official Symbol
Nol4lprovided by MGI
Official Full Name
nucleolar protein 4-likeprovided by MGI
Primary source
MGI:MGI:1918765
See related
Ensembl:ENSMUSG00000061411 AllianceGenome:MGI:1918765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1636; 4931410H15; 8430427H17Rik
Summary
Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including gallbladder; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human NOL4L (nucleolar protein 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 47.6), whole brain E14.5 (RPKM 15.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 75.41 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153249381..153371869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153407461..153530239, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2500004C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7869 Neighboring gene STARR-seq mESC enhancer starr_06089 Neighboring gene STARR-positive B cell enhancer ABC_E7870 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene predicted gene 14472 Neighboring gene RIKEN cDNA 4930404H24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153351610-153351793 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153351903-153352104 Neighboring gene STARR-seq mESC enhancer starr_06100 Neighboring gene STARR-seq mESC enhancer starr_06102 Neighboring gene COMM domain containing 7 Neighboring gene DNA methyltransferase 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer. Lin F, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33940382
  2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
    Title: NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleolar protein 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001986.3 → NP_001001986.2  nucleolar protein 4-like isoform 1

    See identical proteins and their annotated locations for NP_001001986.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AL844144
    Consensus CDS
    CCDS50757.1
    UniProtKB/TrEMBL
    Q3TZG8, Q52KQ8
    Related
    ENSMUSP00000105407.2, ENSMUST00000109784.2

  2. NM_001134300.3 → NP_001127772.1  nucleolar protein 4-like isoform 2

    See identical proteins and their annotated locations for NP_001127772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AL844144
    Consensus CDS
    CCDS50758.1
    UniProtKB/TrEMBL
    Q3UH85
    Related
    ENSMUSP00000036571.8, ENSMUST00000035346.14

  3. NM_001408233.1 → NP_001395162.1  nucleolar protein 4-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844144
    UniProtKB/TrEMBL
    Q3TZG8

  4. NM_001408234.1 → NP_001395163.1  nucleolar protein 4-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844144
    UniProtKB/TrEMBL
    Q3TZG8

  5. NM_001408235.1 → NP_001395164.1  nucleolar protein 4-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL844144

  6. NM_001408236.1 → NP_001395165.1  nucleolar protein 4-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL844144

  7. NM_001408237.1 → NP_001395166.1  nucleolar protein 4-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL844144

  8. NM_001408238.1 → NP_001395167.1  nucleolar protein 4-like isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL844144

  9. NM_001408239.1 → NP_001395168.1  nucleolar protein 4-like isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL844144

  10. NM_001408240.1 → NP_001395169.1  nucleolar protein 4-like isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL844144

  11. NM_001408241.1 → NP_001395170.1  nucleolar protein 4-like isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL844144

  12. NM_001408242.1 → NP_001395171.1  nucleolar protein 4-like isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL844144

  13. NM_001408243.1 → NP_001395172.1  nucleolar protein 4-like isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL844144

  14. NM_001408244.1 → NP_001395173.1  nucleolar protein 4-like isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL844144

  15. NM_001408245.1 → NP_001395174.1  nucleolar protein 4-like isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL844144

RNA

  1. NR_176615.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844144

  2. NR_176616.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844144

  3. NR_176617.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844144
    Related
    ENSMUST00000129385.8

  4. NR_176618.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844144

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    153249381..153371869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239636.3 → XP_011237938.1  nucleolar protein 4-like isoform X10

    UniProtKB/TrEMBL
    Q52KQ8

  2. XM_006499781.4 → XP_006499844.1  nucleolar protein 4-like isoform X3

    UniProtKB/Swiss-Prot
    Q6DIB4
    Conserved Domains (1) summary
    pfam17921
    Location:32 → 86
    Integrase_H2C2; Integrase zinc binding domain

  3. XM_006499780.4 → XP_006499843.1  nucleolar protein 4-like isoform X2

    UniProtKB/Swiss-Prot
    Q6DIB4
    Conserved Domains (1) summary
    pfam17921
    Location:51 → 105
    Integrase_H2C2; Integrase zinc binding domain

  4. XM_006499784.5 → XP_006499847.1  nucleolar protein 4-like isoform X5

    See identical proteins and their annotated locations for XP_006499847.1

    UniProtKB/Swiss-Prot
    Q6DIB4

  5. XM_006499783.5 → XP_006499846.1  nucleolar protein 4-like isoform X5

    See identical proteins and their annotated locations for XP_006499846.1

    UniProtKB/Swiss-Prot
    Q6DIB4

  6. XM_036162331.1 → XP_036018224.1  nucleolar protein 4-like isoform X8

    UniProtKB/TrEMBL
    Q3TZG8, Q52KQ8

  7. XM_006499786.4 → XP_006499849.1  nucleolar protein 4-like isoform X8

    See identical proteins and their annotated locations for XP_006499849.1

    UniProtKB/TrEMBL
    Q3TZG8, Q52KQ8

  8. XM_006499788.5 → XP_006499851.1  nucleolar protein 4-like isoform X8

    See identical proteins and their annotated locations for XP_006499851.1

    UniProtKB/TrEMBL
    Q3TZG8, Q52KQ8

  9. XM_011239629.2 → XP_011237931.1  nucleolar protein 4-like isoform X6

    See identical proteins and their annotated locations for XP_011237931.1

    UniProtKB/TrEMBL
    Q52KQ8

  10. XM_011239633.4 → XP_011237935.1  nucleolar protein 4-like isoform X6

    See identical proteins and their annotated locations for XP_011237935.1

    UniProtKB/TrEMBL
    Q52KQ8

  11. XM_036162333.1 → XP_036018226.1  nucleolar protein 4-like isoform X9

    UniProtKB/TrEMBL
    Q52KQ8

  12. XM_011239632.3 → XP_011237934.1  nucleolar protein 4-like isoform X6

    See identical proteins and their annotated locations for XP_011237934.1

    UniProtKB/TrEMBL
    Q52KQ8

  13. XM_011239631.3 → XP_011237933.1  nucleolar protein 4-like isoform X6

    See identical proteins and their annotated locations for XP_011237933.1

    UniProtKB/TrEMBL
    Q52KQ8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DIB4.1 GenPept UniProtKB/Swiss-Prot:Q6DIB4

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