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Pla2g4e phospholipase A2, group IVE [ Mus musculus (house mouse) ]

Gene ID: 329502, updated on 11-Apr-2024

Summary

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Official Symbol
Pla2g4eprovided by MGI
Official Full Name
phospholipase A2, group IVEprovided by MGI
Primary source
MGI:MGI:1919144
See related
Ensembl:ENSMUSG00000050211 AllianceGenome:MGI:1919144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230096D22; Pla2epsilon; 2310026J01Rik
Summary
Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process and positive regulation of endocytic recycling. Located in early endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PLA2G4E (phospholipase A2 group IVE). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.5), cortex adult (RPKM 3.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.24 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119996893..120075816, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120166412..120245630, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 28042 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_05504 Neighboring gene STARR-positive B cell enhancer ABC_E226 Neighboring gene predicted gene, 52575 Neighboring gene STARR-seq mESC enhancer starr_05506 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVD Neighboring gene phospholipase A2, group IVF

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A(2)ε in an ex vivo murine model of brain ischemia. Rahman SMK, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2022 Dec. PMID 35988872
  2. Group IVE cytosolic phospholipase A(2) limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine. Liang L, et al. FASEB J, 2022 May. PMID 35478358
  3. A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines. Ogura Y, et al. Nat Chem Biol, 2016 Sep. PMID 27399000, Free PMC Article
  4. Cytosolic phospholipase A₂ε drives recycling through the clathrin-independent endocytic route. Capestrano M, et al. J Cell Sci, 2014 Mar 1. PMID 24413173
  5. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca(2+)-dependent N-acyltransferase. Hussain Z, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 May. PMID 29447909

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
    Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytosolic phospholipase A2 epsilon
Names
cPLA2-epsilon
calcium-dependent N-acyltransferase
phospholipase A2, group 4E
NP_001350019.1
NP_001350020.1
NP_001382399.1
NP_808513.2
XP_006499833.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363090.1 → NP_001350019.1  cytosolic phospholipase A2 epsilon isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL833774, AL844608, BX000525
    UniProtKB/TrEMBL
    B2RQF4
    Conserved Domains (2) summary
    cl11396
    Location:239 → 781
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl14603
    Location:1 → 101
    C2; C2 domain

  2. NM_001363091.1 → NP_001350020.1  cytosolic phospholipase A2 epsilon isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL833774, AL844608, BC066085
    Conserved Domains (1) summary
    cl11396
    Location:6 → 497
    Patatin_and_cPLA2; Patatins and Phospholipases

  3. NM_001395470.1 → NP_001382399.1  cytosolic phospholipase A2 epsilon isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL833774, AL844608, BX000525
    UniProtKB/TrEMBL
    B2RQF4
    Conserved Domains (3) summary
    cd07201
    Location:284 → 826
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:38 → 146
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:178 → 285
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain

  4. NM_177845.4 → NP_808513.2  cytosolic phospholipase A2 epsilon isoform 1

    See identical proteins and their annotated locations for NP_808513.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB195277, AL833774, AL844608
    Consensus CDS
    CCDS16616.1
    UniProtKB/Swiss-Prot
    Q50L42, Q8BX44
    UniProtKB/TrEMBL
    B2RQF4
    Related
    ENSMUSP00000087525.5, ENSMUST00000090071.5
    Conserved Domains (3) summary
    cd07201
    Location:328 → 870
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:82 → 190
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:324 → 811
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119996893..120075816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499770.5 → XP_006499833.2  cytosolic phospholipase A2 epsilon isoform X1

    UniProtKB/TrEMBL
    B2RQF4
    Conserved Domains (3) summary
    cd07201
    Location:261 → 803
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:15 → 123
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:155 → 262
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q50L42.1 GenPept UniProtKB/Swiss-Prot:Q50L42

Gene LinkOut

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