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Myo3b myosin IIIB [ Mus musculus (house mouse) ]

Gene ID: 329421, updated on 21-Apr-2024

Summary

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Official Symbol
Myo3bprovided by MGI
Official Full Name
myosin IIIBprovided by MGI
Primary source
MGI:MGI:2448580
See related
Ensembl:ENSMUSG00000042064 AllianceGenome:MGI:2448580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430065P19Rik
Summary
Enables microfilament motor activity and protein serine/threonine kinase activity. Involved in auditory receptor cell stereocilium organization; cochlea morphogenesis; and sensory perception of sound. Acts upstream of or within positive regulation of filopodium assembly; protein phosphorylation; and regulation of actin filament length. Located in filopodium tip; photoreceptor inner segment; and photoreceptor outer segment. Is active in stereocilium tip. Is expressed in several structures, including genitourinary system; nervous system; and submandibular gland. Orthologous to human MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 8.0), kidney adult (RPKM 0.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
2 C2; 2 41.05 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69869464..70259542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70039126..70429195)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11134 Neighboring gene STARR-seq mESC enhancer starr_04746 Neighboring gene STARR-positive B cell enhancer ABC_E508 Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene STARR-seq mESC enhancer starr_04748 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene STARR-positive B cell enhancer ABC_E9515 Neighboring gene STARR-seq mESC enhancer starr_04749 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene STARR-seq mESC enhancer starr_04750 Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757 Neighboring gene STARR-seq mESC enhancer starr_04758 Neighboring gene STARR-seq mESC enhancer starr_04760 Neighboring gene ribosomal protein L9, pseudogene 7 Neighboring gene trans-acting transcription factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse class III myosins: kinase activity and phosphorylation sites. Dalal JS, et al. J Neurochem, 2011 Nov. PMID 21895655, Free PMC Article
  2. Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Ebrahim S, et al. Nat Commun, 2016 Mar 1. PMID 26926603, Free PMC Article
  3. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Merritt RC, et al. Curr Biol, 2012 Feb 21. PMID 22264607, Free PMC Article
  4. Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments. Katti C, et al. Exp Eye Res, 2009 Aug. PMID 19332056, Free PMC Article
  5. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, et al. J Cell Biol, 2016 Jan 18. PMID 26754646, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in auditory receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of filopodium assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin filament length IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament length IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin filament length IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in filopodium tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium tip IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in stereocilium tip EXP
Inferred from Experiment
more info
 PubMed 
is_active_in stereocilium tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stereocilium tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin-IIIb
Names
myosin IIIB1
myosin IIIB2
NP_796350.2
XP_006499808.1
XP_006499813.1
XP_017174526.1
XP_017174527.1
XP_017174528.1
XP_017174529.1
XP_017174530.1
XP_017174531.1
XP_017174532.1
XP_017174534.1
XP_030107661.1
XP_036018214.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177376.5 → NP_796350.2  myosin-IIIb

    See identical proteins and their annotated locations for NP_796350.2

    Status: VALIDATED

    Source sequence(s)
    AL845263, AL929164, AL929249
    Consensus CDS
    CCDS38139.1
    UniProtKB/TrEMBL
    F8VQ79
    Related
    ENSMUSP00000055362.4, ENSMUST00000060208.11
    Conserved Domains (4) summary
    smart00220
    Location:43 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00242
    Location:362 → 1069
    MYSc; Myosin. Large ATPases
    cd06639
    Location:20 → 310
    STKc_myosinIIIB_N; N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin
    cd01379
    Location:373 → 1062
    MYSc_Myo3; class III myosin, motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    69869464..70259542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319039.1 → XP_017174528.1  myosin-IIIb isoform X3

    UniProtKB/Swiss-Prot
    A2AR19, Q1EG26, Q1EG27
    Related
    ENSMUSP00000107862.2, ENSMUST00000112243.8
    Conserved Domains (2) summary
    cd01379
    Location:345 → 1034
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006499745.5 → XP_006499808.1  myosin-IIIb isoform X1

    Conserved Domains (2) summary
    cd01379
    Location:345 → 1051
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  3. XM_017319038.3 → XP_017174527.1  myosin-IIIb isoform X2

    Conserved Domains (2) summary
    cd01379
    Location:345 → 1037
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  4. XM_017319040.3 → XP_017174529.1  myosin-IIIb isoform X4

    Conserved Domains (2) summary
    cd01379
    Location:323 → 1029
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 260
    PKc_like; Protein Kinases, catalytic domain

  5. XM_006499750.5 → XP_006499813.1  myosin-IIIb isoform X5

    Conserved Domains (2) summary
    cd01379
    Location:310 → 1016
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 247
    PKc_like; Protein Kinases, catalytic domain

  6. XM_017319042.3 → XP_017174531.1  myosin-IIIb isoform X7

    Conserved Domains (2) summary
    cd01379
    Location:345 → 1051
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  7. XM_017319043.3 → XP_017174532.1  myosin-IIIb isoform X8

    Conserved Domains (2) summary
    cd01379
    Location:345 → 1051
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017319041.2 → XP_017174530.1  myosin-IIIb isoform X6

    Conserved Domains (2) summary
    cd01379
    Location:345 → 1051
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  9. XM_017319045.1 → XP_017174534.1  myosin-IIIb isoform X10

    Conserved Domains (2) summary
    cl22853
    Location:345 → 862
    Motor_domain; Myosin and Kinesin motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  10. XM_030251801.1 → XP_030107661.1  myosin-IIIb isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:1 → 238
    PKc_like; Protein Kinases, catalytic domain

  11. XM_017319037.3 → XP_017174526.1  myosin-IIIb isoform X1

    Conserved Domains (2) summary
    cd01379
    Location:345 → 1051
    MYSc_Myo3; class III myosin, motor domain
    cl21453
    Location:1 → 282
    PKc_like; Protein Kinases, catalytic domain

  12. XM_036162321.1 → XP_036018214.1  myosin-IIIb isoform X9

    Conserved Domains (4) summary
    smart00015
    Location:886 → 908
    IQ; Calmodulin-binding motif
    cd01379
    Location:140 → 846
    MYSc_Myo3; class III myosin, motor domain
    cd22307
    Location:878 → 926
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
    cl21453
    Location:34 → 77
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004940647.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042509.1: Suppressed sequence

    Description
    NM_001042509.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1EG27.2 GenPept UniProtKB/Swiss-Prot:Q1EG27

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