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Nostrin nitric oxide synthase trafficker [ Mus musculus (house mouse) ]

Gene ID: 329416, updated on 21-Apr-2024

Summary

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Official Symbol
Nostrinprovided by MGI
Official Full Name
nitric oxide synthase traffickerprovided by MGI
Primary source
MGI:MGI:3606242
See related
Ensembl:ENSMUSG00000034738 AllianceGenome:MGI:3606242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Daip2; mDaIP2
Summary
Enables DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 11.0), large intestine adult (RPKM 4.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C2; 2 39.58 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (68966144..69019674)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69135800..69189330)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ceramide synthase 6 Neighboring gene predicted gene, 52515 Neighboring gene STARR-seq mESC enhancer starr_04722 Neighboring gene STARR-seq mESC enhancer starr_04727 Neighboring gene predicted gene, 39840 Neighboring gene STARR-positive B cell enhancer ABC_E412 Neighboring gene STARR-seq mESC enhancer starr_04729 Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene glucose-6-phosphatase, catalytic, 2 Neighboring gene STARR-seq mESC enhancer starr_04731 Neighboring gene ATP-binding cassette, sub-family B member 11 Neighboring gene STARR-seq mESC enhancer starr_04732

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of the cis-element and bZIP DNA binding motifs for the autogenous negative control of mouse NOSTRIN. Bae SH, et al. Biochem Biophys Res Commun, 2014 Jan 17. PMID 24361894
  2. Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling. Chakraborty S, et al. J Biol Chem, 2017 Apr 21. PMID 28235804, Free PMC Article
  3. The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function. Kovacevic I, et al. Circ Res, 2015 Aug 14. PMID 26169369
  4. Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter. Kim HW, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16171775
  5. Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN. Choi YJ, et al. Biochem Biophys Res Commun, 2005 Jan 21. PMID 15596140

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the SH3 domain of NOSTRIN is involved in the NOSTRIN-TRAF6 interaction and is required for NOSTRIN-induced down-regulation of endothelial cell proteins
    Title: Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling.
  2. NOSTRIN is crucial for the localization and function of the muscarinic M3 receptor at the plasma membrane in the aorta.
    Title: The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function.
  3. mouse NOSTRIN acts as a transcriptional repressor by binding to the cis-element through its bZIP motif.
    Title: Identification of the cis-element and bZIP DNA binding motifs for the autogenous negative control of mouse NOSTRIN.
  4. NOSTRIN participates in FGF signal transduction and vascular development.
    Title: The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
  5. Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN.
    Title: Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression.
  6. The disabled 2 interacting protein 2 represses the expression of its own gene, via a feedback mechanism which involves binding to the promoter region.
    Title: Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter.
  7. shares 82% identity with human NOSTRIN; functions in a different fashion from NOSTRIN and its function may be concerted with that of disabled 2(disabled 2 interacting protein 2)
    Title: Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nostrin
Names
Dab2-interacting protein 2
disabled homolog 2-interacting protein 2
eNOS-trafficking inducer
probable ortholog of human nitric oxide synthase trafficker (NOSTRIN)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181547.3 → NP_853525.3  nostrin

    See identical proteins and their annotated locations for NP_853525.3

    Status: VALIDATED

    Source sequence(s)
    BC069942, BY061165
    Consensus CDS
    CCDS16087.1
    UniProtKB/Swiss-Prot
    Q6WKZ7, Q7TSK5, Q8BWC2
    Related
    ENSMUSP00000036923.8, ENSMUST00000041865.8
    Conserved Domains (2) summary
    cd07658
    Location:8 → 250
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:443 → 494
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    68966144..69019674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WKZ7.2 GenPept UniProtKB/Swiss-Prot:Q6WKZ7

Gene LinkOut

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