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Syt14 synaptotagmin XIV [ Mus musculus (house mouse) ]

Gene ID: 329324, updated on 21-Apr-2024

Summary

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Official Symbol
Syt14provided by MGI
Official Full Name
synaptotagmin XIVprovided by MGI
Primary source
MGI:MGI:2444490
See related
Ensembl:ENSMUSG00000016200 AllianceGenome:MGI:2444490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sytXIV; B230320I09Rik
Summary
This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Broad expression in liver E14 (RPKM 2.1), liver E14.5 (RPKM 1.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 97.55 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192564956..192718179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (192882653..193035871, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700065J18 gene Neighboring gene SERTA domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_03467 Neighboring gene predicted gene 15867 Neighboring gene STARR-seq mESC enhancer starr_03468 Neighboring gene 40S ribosomal protein S11-like Neighboring gene predicted gene, 39746 Neighboring gene predicted gene, 31406 Neighboring gene predicted gene, 39747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194913524-194913725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194948976-194949260 Neighboring gene STARR-positive B cell enhancer ABC_E3355 Neighboring gene UTP25 small subunit processome component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. Fukuda M. J Biochem, 2003 May. PMID 12801916
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
synaptotagmin-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301370.1 → NP_001288299.1  synaptotagmin-14 isoform 1

    See identical proteins and their annotated locations for NP_001288299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK045901, AK047918, AL365326, AW121643, BC141262
    Consensus CDS
    CCDS78780.1
    UniProtKB/TrEMBL
    B7ZP31
    Related
    ENSMUSP00000016344.9, ENSMUST00000016344.9
    Conserved Domains (2) summary
    cd08389
    Location:260 → 383
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:416 → 572
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  2. NM_181546.3 → NP_853524.1  synaptotagmin-14 isoform 2

    See identical proteins and their annotated locations for NP_853524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK045901, AK047918, AL365326, AW121643, BC145602
    Consensus CDS
    CCDS48489.1
    UniProtKB/Swiss-Prot
    Q7TN84
    Related
    ENSMUSP00000142190.2, ENSMUST00000195354.6
    Conserved Domains (2) summary
    cd08389
    Location:260 → 383
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:416 → 553
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    192564956..192718179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255031.2 → XP_030110891.1  synaptotagmin-14 isoform X8

    Conserved Domains (2) summary
    cd08389
    Location:133 → 256
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:289 → 426
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  2. XM_011238938.3 → XP_011237240.1  synaptotagmin-14 isoform X7

    Conserved Domains (2) summary
    cd08389
    Location:133 → 256
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:289 → 445
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  3. XM_030255032.2 → XP_030110892.1  synaptotagmin-14 isoform X9

    Conserved Domains (2) summary
    cd08389
    Location:107 → 230
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:263 → 419
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  4. XM_036165952.1 → XP_036021845.1  synaptotagmin-14 isoform X4

    Conserved Domains (2) summary
    cd08389
    Location:222 → 345
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:378 → 534
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  5. XM_030255030.2 → XP_030110890.1  synaptotagmin-14 isoform X4

    Conserved Domains (2) summary
    cd08389
    Location:222 → 345
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:378 → 534
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  6. XM_006497256.3 → XP_006497319.1  synaptotagmin-14 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SVE7
    Related
    ENSMUSP00000151129.2, ENSMUST00000215093.2
    Conserved Domains (2) summary
    cd08389
    Location:543 → 666
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:699 → 836
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  7. XM_006497255.3 → XP_006497318.1  synaptotagmin-14 isoform X1

    Conserved Domains (2) summary
    cd08389
    Location:543 → 666
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
    cd08408
    Location:699 → 855
    C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

  8. XM_030255033.2 → XP_030110893.1  synaptotagmin-14 isoform X10

    Conserved Domains (1) summary
    cd08389
    Location:222 → 345
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16

  9. XM_006497257.1 → XP_006497320.1  synaptotagmin-14 isoform X3

    Conserved Domains (1) summary
    cd08389
    Location:543 → 666
    C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16

  10. XM_036165957.1 → XP_036021850.1  synaptotagmin-14 isoform X5

  11. XM_011238937.2 → XP_011237239.1  synaptotagmin-14 isoform X6

RNA

  1. XR_003956138.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN84.1 GenPept UniProtKB/Swiss-Prot:Q7TN84

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