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Ppp1r12b protein phosphatase 1, regulatory subunit 12B [ Mus musculus (house mouse) ]

Gene ID: 329251, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp1r12bprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 12Bprovided by MGI
Primary source
MGI:MGI:1916417
See related
Ensembl:ENSMUSG00000073557 AllianceGenome:MGI:1916417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mypt2; 1810037O03Rik; 9530009M10Rik
Summary
Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to be involved in signal transduction. Located in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 30.2), heart adult (RPKM 14.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.24 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134682396..134883699, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134754658..134955963, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:136456618-136456805 Neighboring gene STARR-seq mESC enhancer starr_02340 Neighboring gene MGAT4 family, member E Neighboring gene STARR-seq mESC enhancer starr_02343 Neighboring gene lysine demethylase 5B Neighboring gene STARR-seq mESC enhancer starr_02345 Neighboring gene synaptotagmin II Neighboring gene predicted gene, 32670 Neighboring gene predicted gene, 57568 Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene predicted gene, 51748 Neighboring gene microRNA 5104b Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3. Hu T, et al. J Biol Chem, 2023 Apr. PMID 36889588, Free PMC Article
  2. Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function. Mizutani H, et al. Circ J, 2010 Jan. PMID 19966500
  3. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B. Liu K, et al. EBioMedicine, 2020 Nov. PMID 33096475, Free PMC Article
  4. Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations. Hughes JJ, et al. Am J Hum Genet, 2020 Jan 2. PMID 31883643, Free PMC Article
  5. Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. Arimura T, et al. J Biol Chem, 2001 Mar 2. PMID 11067852

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
    Title: The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
  2. Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3.
    Title: Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3.
  3. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
    Title: Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
  4. MYPT2 is truly the regulatory subunit of cardiac myosin phosphatase in-vivo and plays a significant role in modulating cardiac function.
    Title: Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in A band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 12B
Names
myosin phosphatase target subunit 2
myosin phosphatase-targeting subunit 2
protein phosphatase 1, regulatory (inhibitor) subunit 12B
NP_001074776.1
NP_001355756.1
NP_001355758.1
XP_006529770.1
XP_006529776.1
XP_017176766.1
XP_017176767.1
XP_017176768.1
XP_036021781.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081307.2 → NP_001074776.1  protein phosphatase 1 regulatory subunit 12B isoform 1

    See identical proteins and their annotated locations for NP_001074776.1

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC131591
    Consensus CDS
    CCDS35717.1
    UniProtKB/TrEMBL
    A6H644
    Related
    ENSMUSP00000131406.2, ENSMUST00000168381.8
    Conserved Domains (5) summary
    cd00204
    Location:85 → 269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:219 → 269
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:875 → 981
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]

  2. NM_001368827.1 → NP_001355756.1  protein phosphatase 1 regulatory subunit 12B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC131591
    Consensus CDS
    CCDS87881.1
    UniProtKB/Swiss-Prot
    Q8BG95, Q8BXY7, Q9D8S6
    Related
    ENSMUSP00000047463.7, ENSMUST00000045665.13
    Conserved Domains (4) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:875 → 975
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  3. NM_001368829.1 → NP_001355758.1  protein phosphatase 1 regulatory subunit 12B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC131591
    Conserved Domains (4) summary
    PLN03192
    Location:1 → 89
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:53 → 133
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:707 → 807
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134682396..134883699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529713.5 → XP_006529776.1  protein phosphatase 1 regulatory subunit 12B isoform X6

    UniProtKB/TrEMBL
    A0A571BGD8
    Related
    ENSMUSP00000158804.2, ENSMUST00000238280.2
    Conserved Domains (1) summary
    pfam15898
    Location:85 → 185
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  2. XM_017321279.3 → XP_017176768.1  protein phosphatase 1 regulatory subunit 12B isoform X4

    Conserved Domains (6) summary
    PLN03192
    Location:1 → 89
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam04388
    Location:362 → 681
    Hamartin; Hamartin protein
    pfam12796
    Location:53 → 133
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:768 → 874
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    pfam17823
    Location:367 → 504
    DUF5585; Family of unknown function (DUF5585)

  3. XM_006529707.5 → XP_006529770.1  protein phosphatase 1 regulatory subunit 12B isoform X1

    Conserved Domains (6) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam04388
    Location:530 → 849
    Hamartin; Hamartin protein
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:936 → 1042
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    pfam17823
    Location:535 → 672
    DUF5585; Family of unknown function (DUF5585)

  4. XM_036165888.1 → XP_036021781.1  protein phosphatase 1 regulatory subunit 12B isoform X5

    Conserved Domains (5) summary
    PLN03192
    Location:1 → 89
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:53 → 133
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:707 → 813
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl40436
    Location:442 → 494
    IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

  5. XM_017321277.3 → XP_017176766.1  protein phosphatase 1 regulatory subunit 12B isoform X2

    Conserved Domains (6) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam04388
    Location:530 → 849
    Hamartin; Hamartin protein
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:936 → 1036
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    pfam17823
    Location:535 → 672
    DUF5585; Family of unknown function (DUF5585)

  6. XM_017321278.3 → XP_017176767.1  protein phosphatase 1 regulatory subunit 12B isoform X3

    Conserved Domains (5) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam04388
    Location:530 → 849
    Hamartin; Hamartin protein
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam17823
    Location:535 → 672
    DUF5585; Family of unknown function (DUF5585)

RNA

  1. XR_387177.5 RNA Sequence

    Related
    ENSMUST00000132025.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015606.4: Suppressed sequence

    Description
    NR_015606.4: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG95.2 GenPept UniProtKB/Swiss-Prot:Q8BG95

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