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Abi2 abl interactor 2 [ Mus musculus (house mouse) ]

Gene ID: 329165, updated on 21-Apr-2024

Summary

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Official Symbol
Abi2provided by MGI
Official Full Name
abl interactor 2provided by MGI
Primary source
MGI:MGI:106913
See related
Ensembl:ENSMUSG00000026782 AllianceGenome:MGI:106913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AblBP3; ArgBP1; C130078H13; 8430425M24Rik
Summary
Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin cytoskeleton organization; and regulation of dendritic spine morphogenesis. Acts upstream of or within several processes, including camera-type eye development; dendrite development; and learning or memory. Located in adherens junction; dendrite; and glutamatergic synapse. Is active in dendritic spine and postsynaptic actin cytoskeleton. Is expressed in several structures, including fronto-nasal process; future brain; intestine smooth muscle circular layer; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 18.9), CNS E18 (RPKM 17.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C2; 1 30.47 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60444927..60521104)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60405768..60481945)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neurobeachin like 1 Neighboring gene STARR-seq mESC enhancer starr_01063 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_01064 Neighboring gene STARR-seq mESC enhancer starr_01065 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_01070 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene SEC61 translocon subunit gamma, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_01072 Neighboring gene predicted gene 11578

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Dai Z, et al. Genes Dev, 1998 May 15. PMID 9585502, Free PMC Article
  2. WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. Xie MJ, et al. Cereb Cortex, 2013 Jun. PMID 22617848
  3. Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. Zipfel PA, et al. Curr Biol, 2006 Jan 10. PMID 16401422
  4. Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. Echarri A, et al. Mol Cell Biol, 2004 Jun. PMID 15143189, Free PMC Article
  5. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Ring C, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173240, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that WAVE2-Abi2 complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape.
    Title: WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration.
  2. TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2
    Title: Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
  3. findings support a role for Abi2 in the regulation of cytoskeletal dynamics at adherens junctions and dendritic spines, which is critical for intercellular connectivity, cell morphogenesis, and cognitive functions
    Title: ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
  4. NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.
    Title: NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90836, MGC90855

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens fiber cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zonula adherens assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
abl interactor 2
Names
abelson interactor 2
abi-2
abl-binding protein 3
arg-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198570.2 → NP_001185499.1  abl interactor 2 isoform 1

    See identical proteins and their annotated locations for NP_001185499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC158969
    Consensus CDS
    CCDS78593.1
    UniProtKB/TrEMBL
    Q6AXD2
    Related
    ENSMUSP00000140274.2, ENSMUST00000188618.7
    Conserved Domains (2) summary
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR
    cl17036
    Location:452 → 486
    SH3; Src Homology 3 domain superfamily

  2. NM_001198571.2 → NP_001185500.1  abl interactor 2 isoform 2

    See identical proteins and their annotated locations for NP_001185500.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC158969
    Consensus CDS
    CCDS78594.1
    UniProtKB/TrEMBL
    Q6AXH6
    Related
    ENSMUSP00000141068.2, ENSMUST00000189980.7
    Conserved Domains (2) summary
    cd11972
    Location:419 → 479
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  3. NM_001404705.1 → NP_001391634.1  abl interactor 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158969

  4. NM_001404706.1 → NP_001391635.1  abl interactor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158969

  5. NM_001404707.1 → NP_001391636.1  abl interactor 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158969

  6. NM_001404708.1 → NP_001391637.1  abl interactor 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158969

  7. NM_001404709.1 → NP_001391638.1  abl interactor 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158969

  8. NM_001404710.1 → NP_001391639.1  abl interactor 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158969

  9. NM_001404711.1 → NP_001391640.1  abl interactor 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC158969

  10. NM_001404712.1 → NP_001391641.1  abl interactor 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158969

  11. NM_001404713.1 → NP_001391642.1  abl interactor 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC158969
    UniProtKB/TrEMBL
    A0A087WPP8
    Related
    ENSMUSP00000139867.2, ENSMUST00000187709.7

  12. NM_001404714.1 → NP_001391643.1  abl interactor 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC158969

  13. NM_001404715.1 → NP_001391644.1  abl interactor 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC158969

  14. NM_001404716.1 → NP_001391645.1  abl interactor 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC158969

  15. NM_001404717.1 → NP_001391646.1  abl interactor 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC158969

  16. NM_001404718.1 → NP_001391647.1  abl interactor 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC158969

  17. NM_001404719.1 → NP_001391648.1  abl interactor 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC158969

  18. NM_001404720.1 → NP_001391649.1  abl interactor 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC158969

  19. NM_001404721.1 → NP_001391650.1  abl interactor 2 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC158969

  20. NM_198127.3 → NP_937760.1  abl interactor 2 isoform 3

    See identical proteins and their annotated locations for NP_937760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC158969
    Consensus CDS
    CCDS14991.1
    UniProtKB/Swiss-Prot
    P62484
    Related
    ENSMUSP00000058754.9, ENSMUST00000052332.15
    Conserved Domains (2) summary
    cd11972
    Location:385 → 445
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    60444927..60521104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496080.4 → XP_006496143.1  abl interactor 2 isoform X13

    Conserved Domains (2) summary
    cd11972
    Location:420 → 480
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  2. XM_006496085.4 → XP_006496148.1  abl interactor 2 isoform X21

    Conserved Domains (2) summary
    cd11972
    Location:391 → 451
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  3. XM_017321240.2 → XP_017176729.1  abl interactor 2 isoform X2

    Conserved Domains (3) summary
    cd11972
    Location:480 → 540
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:199 → 414
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR

  4. XM_036165783.1 → XP_036021676.1  abl interactor 2 isoform X14

    Conserved Domains (2) summary
    cd11972
    Location:419 → 479
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  5. XM_036165799.1 → XP_036021692.1  abl interactor 2 isoform X24

    Conserved Domains (2) summary
    cd11972
    Location:371 → 431
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  6. XM_030255006.1 → XP_030110866.1  abl interactor 2 isoform X4

    Conserved Domains (3) summary
    cd11972
    Location:474 → 534
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:263 → 399
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  7. XM_030255012.1 → XP_030110872.1  abl interactor 2 isoform X11

    Conserved Domains (3) summary
    cd11972
    Location:426 → 486
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:215 → 351
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  8. XM_006496084.4 → XP_006496147.1  abl interactor 2 isoform X19

    UniProtKB/TrEMBL
    A0A087WRS3
    Related
    ENSMUSP00000140750.2, ENSMUST00000188594.7
    Conserved Domains (3) summary
    cd11972
    Location:397 → 457
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:215 → 342
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  9. XM_030255013.1 → XP_030110873.1  abl interactor 2 isoform X12

    Conserved Domains (3) summary
    cd11972
    Location:425 → 485
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:214 → 350
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 163
    Abi_HHR; Abl-interactor HHR

  10. XM_036165790.1 → XP_036021683.1  abl interactor 2 isoform X20

    Conserved Domains (3) summary
    cd11972
    Location:396 → 456
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:214 → 341
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  11. XM_036165801.1 → XP_036021694.1  abl interactor 2 isoform X26

    Conserved Domains (2) summary
    cd11972
    Location:364 → 424
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    pfam07815
    Location:93 → 156
    Abi_HHR; Abl-interactor HHR

  12. XM_017321247.2 → XP_017176736.1  abl interactor 2 isoform X18

    Conserved Domains (3) summary
    cd11972
    Location:402 → 462
    SH3_Abi2; Src homology 3 domain of Abl Interactor 2
    PHA03247
    Location:220 → 347
    PHA03247; large tegument protein UL36; Provisional
    pfam07815
    Location:93 → 169
    Abi_HHR; Abl-interactor HHR
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62484.1 GenPept UniProtKB/Swiss-Prot:P62484

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