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Scd4 stearoyl-coenzyme A desaturase 4 [ Mus musculus (house mouse) ]

Gene ID: 329065, updated on 8-Feb-2024

Summary

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Official Symbol
Scd4provided by MGI
Official Full Name
stearoyl-coenzyme A desaturase 4provided by MGI
Primary source
MGI:MGI:2670997
See related
Ensembl:ENSMUSG00000050195 AllianceGenome:MGI:2670997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACOD4
Summary
Enables palmitoyl-CoA 9-desaturase activity and stearoyl-CoA 9-desaturase activity. Involved in cellular response to nutrient and monounsaturated fatty acid biosynthetic process. Acts upstream of or within fatty acid biosynthetic process. Is integral component of membrane. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 44.2), subcutaneous fat pad adult (RPKM 43.9) and 9 other tissues See more
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Genomic context

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Location:
19 C3; 19 37.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44321765..44335182)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44333326..44346743)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44358612-44358721 Neighboring gene STARR-positive B cell enhancer ABC_E4283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44368225-44368334 Neighboring gene STARR-positive B cell enhancer ABC_E2528 Neighboring gene predicted gene, 41853 Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene microRNA 5114 Neighboring gene STARR-seq mESC enhancer starr_46229 Neighboring gene STARR-seq mESC enhancer starr_46230 Neighboring gene STARR-positive B cell enhancer ABC_E4284 Neighboring gene STARR-positive B cell enhancer ABC_E972 Neighboring gene STARR-positive B cell enhancer ABC_E7663 Neighboring gene STARR-seq mESC enhancer starr_46234 Neighboring gene stearoyl-Coenzyme A desaturase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:44531852-44532152 Neighboring gene predicted gene, 35406

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes. Gan AM, et al. Int J Mol Sci, 2022 Sep 9. PMID 36142371, Free PMC Article
  2. Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Escobedo N, et al. Development, 2013 Jul. PMID 23760952, Free PMC Article
  3. Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. Miyazaki M, et al. J Lipid Res, 2006 Apr. PMID 16443825
  4. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. Miyazaki M, et al. J Biol Chem, 2003 Sep 5. PMID 12815040
  5. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes.
    Title: Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes.
  2. Results show that mouse stearoyl-coenzyme A desaturase (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse SCD3 uses C16:0 but not C18:0.
    Title: Identification of mouse palmitoyl-coenzyme A Delta9-desaturase.
  3. SCD4 demonstrates tissue-specific regulation by leptin and dietary factors.
    Title: Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC48154

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-CoA 9-desaturase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables stearoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables stearoyl-CoA 9-desaturase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monounsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
stearoyl-CoA desaturase 4
Names
acyl-CoA desaturase 4
delta(9)-desaturase 4
fatty acid desaturase 4
NP_899039.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183216.3 → NP_899039.2  stearoyl-CoA desaturase 4

    See identical proteins and their annotated locations for NP_899039.2

    Status: VALIDATED

    Source sequence(s)
    AC123853
    Consensus CDS
    CCDS29849.1
    UniProtKB/Swiss-Prot
    B9EIY5, Q6T707
    Related
    ENSMUSP00000059860.9, ENSMUST00000058856.9
    Conserved Domains (2) summary
    cd03505
    Location:94 → 331
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:94 → 300
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44321765..44335182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6T707.1 GenPept UniProtKB/Swiss-Prot:Q6T707

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