U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arhgef37 Rho guanine nucleotide exchange factor 37 [ Mus musculus (house mouse) ]

Gene ID: 328967, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Arhgef37provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 37provided by MGI
Primary source
MGI:MGI:3045339
See related
Ensembl:ENSMUSG00000045094 AllianceGenome:MGI:3045339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933429F08Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Orthologous to human ARHGEF37 (Rho guanine nucleotide exchange factor 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 2.5), genital fat pad adult (RPKM 2.3) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Arhgef37 in Genome Data Viewer
Location:
18 E1; 18 34.62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61624728..61669994, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61491657..61536928, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene brown adipose tissue enriched long noncoding RNA 10 Neighboring gene predicted gene, 46637 Neighboring gene STARR-seq mESC enhancer starr_44745 Neighboring gene STARR-seq mESC enhancer starr_44746 Neighboring gene STARR-positive B cell enhancer ABC_E9979 Neighboring gene STARR-seq mESC enhancer starr_44748 Neighboring gene casein kinase 1, alpha 1 Neighboring gene VISTA enhancer mm36 Neighboring gene predicted gene, 41747

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho guanine nucleotide exchange factor 37
Names
Rho guanine nucleotide exchange factor (GEF) 37
probable guanine nucleotide exchange factor FLJ41603 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177828.4 → NP_808496.2  rho guanine nucleotide exchange factor 37

    See identical proteins and their annotated locations for NP_808496.2

    Status: VALIDATED

    Source sequence(s)
    AC153155, AK030242, AK177275, CJ045695, CJ131942
    Consensus CDS
    CCDS50302.1
    UniProtKB/Swiss-Prot
    A1IGU4, Q8C0M3
    UniProtKB/TrEMBL
    E9Q5R6
    Related
    ENSMUSP00000130560.2, ENSMUST00000171629.3
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61624728..61669994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526028.5 → XP_006526091.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006526091.1

    UniProtKB/Swiss-Prot
    A1IGU4, Q8C0M3
    UniProtKB/TrEMBL
    E9Q5R6
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

  2. XM_006526027.5 → XP_006526090.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006526090.1

    UniProtKB/Swiss-Prot
    A1IGU4, Q8C0M3
    UniProtKB/TrEMBL
    E9Q5R6
    Conserved Domains (4) summary
    cd07589
    Location:264 → 452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510 → 563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:607 → 663
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34 → 211
    RhoGEF; RhoGEF domain

  3. XM_036161182.1 → XP_036017075.1  rho guanine nucleotide exchange factor 37 isoform X2

    Related
    ENSMUSP00000157463.2, ENSMUST00000236608.2
    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:393 → 449
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

  4. XM_030250512.2 → XP_030106372.1  rho guanine nucleotide exchange factor 37 isoform X2

    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:393 → 449
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

  5. XM_011246947.4 → XP_011245249.1  rho guanine nucleotide exchange factor 37 isoform X2

    See identical proteins and their annotated locations for XP_011245249.1

    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:393 → 449
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

  6. XM_011246946.4 → XP_011245248.1  rho guanine nucleotide exchange factor 37 isoform X2

    See identical proteins and their annotated locations for XP_011245248.1

    Conserved Domains (3) summary
    cd07589
    Location:50 → 238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296 → 349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:393 → 449
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1IGU4.1 GenPept UniProtKB/Swiss-Prot:A1IGU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous