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Mcc mutated in colorectal cancers [ Mus musculus (house mouse) ]

Gene ID: 328949, updated on 5-Mar-2024

Summary

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Official Symbol
Mccprovided by MGI
Official Full Name
mutated in colorectal cancersprovided by MGI
Primary source
MGI:MGI:96930
See related
Ensembl:ENSMUSG00000071856 AllianceGenome:MGI:96930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E330037C19; D18Ertd451e
Summary
Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 10.4), cerebellum adult (RPKM 5.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B3; 18 23.74 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44558127..44945573, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44425060..44812182, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44459 Neighboring gene STARR-seq mESC enhancer starr_44461 Neighboring gene STARR-positive B cell enhancer ABC_E9976 Neighboring gene myotilin Neighboring gene decapping mRNA 2 Neighboring gene STARR-seq mESC enhancer starr_44470 Neighboring gene predicted gene, 52347 Neighboring gene STARR-seq mESC enhancer starr_44475 Neighboring gene STARR-seq mESC enhancer starr_44477 Neighboring gene RIKEN cDNA A930012L18 gene Neighboring gene STARR-seq mESC enhancer starr_44478 Neighboring gene STARR-seq mESC enhancer starr_44479 Neighboring gene STARR-seq mESC enhancer starr_44481 Neighboring gene YTH domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_44482 Neighboring gene STARR-seq mESC enhancer starr_44483 Neighboring gene STARR-seq mESC enhancer starr_44484 Neighboring gene STARR-seq mESC enhancer starr_44486 Neighboring gene predicted gene, 31706 Neighboring gene mortality factor 4 like 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer. Currey N, et al. Cell Mol Gastroenterol Hepatol, 2019. PMID 30831321, Free PMC Article
  2. Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis. Young T, et al. Dev Dyn, 2011 Sep. PMID 22016184
  3. Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. Edwards SK, et al. J Hematol Oncol, 2014 Sep 9. PMID 25200342, Free PMC Article
  4. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Kinzler KW, et al. Science, 1991 Mar 15. PMID 1848370
  5. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Luongo C, et al. Genomics, 1993 Jan. PMID 8094372

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Mcc may promote cancer through a failure to repair inflammation-induced DNA damage.
    Title: Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer.
  2. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells
    Title: Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
colorectal mutant cancer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085373.1 → NP_001078842.1  colorectal mutant cancer protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC137150, AC147551, AK054528, AK158266, BU756994
    Consensus CDS
    CCDS50277.1
    UniProtKB/TrEMBL
    E9PWI3, Q3TYX4
    Related
    ENSMUSP00000087318.6, ENSMUST00000089874.9
    Conserved Domains (4) summary
    cd00051
    Location:24 → 80
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam10506
    Location:577 → 640
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:25 → 78
    EF-hand_7; EF-hand domain pair
    pfam16046
    Location:146 → 271
    FAM76; FAM76 protein

  2. NM_001085374.1 → NP_001078843.1  colorectal mutant cancer protein isoform 2

    See identical proteins and their annotated locations for NP_001078843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC147551, AK054528, BU756994
    Consensus CDS
    CCDS50276.1
    UniProtKB/TrEMBL
    G3UW40, Q3TYX4
    Related
    ENSMUSP00000128032.2, ENSMUST00000164666.6
    Conserved Domains (2) summary
    pfam10506
    Location:402 → 465
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    cl23720
    Location:13 → 134
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    44558127..44945573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161179.1 → XP_036017072.1  colorectal mutant cancer protein isoform X1

    UniProtKB/TrEMBL
    Q3TYX4
    Conserved Domains (2) summary
    COG1196
    Location:615 → 877
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:459 → 523
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  2. XM_006526024.4 → XP_006526087.1  colorectal mutant cancer protein isoform X3

    See identical proteins and their annotated locations for XP_006526087.1

    Conserved Domains (2) summary
    COG1196
    Location:495 → 757
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:339 → 403
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  3. XM_030250510.2 → XP_030106370.1  colorectal mutant cancer protein isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:495 → 757
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:339 → 403
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  4. XM_006526026.5 → XP_006526089.1  colorectal mutant cancer protein isoform X3

    See identical proteins and their annotated locations for XP_006526089.1

    Conserved Domains (2) summary
    COG1196
    Location:495 → 757
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:339 → 403
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  5. XM_006526025.5 → XP_006526088.1  colorectal mutant cancer protein isoform X3

    See identical proteins and their annotated locations for XP_006526088.1

    Conserved Domains (2) summary
    COG1196
    Location:495 → 757
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:339 → 403
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  6. XM_036161181.1 → XP_036017074.1  colorectal mutant cancer protein isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:495 → 757
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10506
    Location:339 → 403
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

  7. XM_006526023.5 → XP_006526086.1  colorectal mutant cancer protein isoform X2

    UniProtKB/TrEMBL
    Q3TYX4
    Conserved Domains (3) summary
    COG1196
    Location:587 → 849
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:36 → 323
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10506
    Location:431 → 494
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033406.1: Suppressed sequence

    Description
    NM_001033406.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version

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