U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubash3a ubiquitin associated and SH3 domain containing, A [ Mus musculus (house mouse) ]

Gene ID: 328795, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ubash3aprovided by MGI
Official Full Name
ubiquitin associated and SH3 domain containing, Aprovided by MGI
Primary source
MGI:MGI:1926074
See related
Ensembl:ENSMUSG00000042345 AllianceGenome:MGI:1926074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TULA; Sts-2; TULA-1; C330001M22; 5830413C03Rik
Summary
Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 15.3), liver E14.5 (RPKM 3.3) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 A3.3- B1; 17 15.84 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31426842..31478655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31207868..31259681)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15318 Neighboring gene trefoil factor 1 Neighboring gene transmembrane protease, serine 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31341993-31342102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31344766-31345042 Neighboring gene STARR-positive B cell enhancer ABC_E3196 Neighboring gene STARR-positive B cell enhancer ABC_E10945 Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene phosphodiesterase 9A Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Chen YG, et al. Sci Rep, 2020 Jul 21. PMID 32694640, Free PMC Article
  2. Suppressor of TCR signaling-2 (STS-2) suppresses arthritis development in mice. Okabe N, et al. Mod Rheumatol, 2018 Jul. PMID 28972439
  3. Structures of the phosphorylated and VO(3)-bound 2H-phosphatase domain of Sts-2. Chen Y, et al. Biochemistry, 2009 Sep 1. PMID 19627098, Free PMC Article
  4. Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity. Chen Y, et al. Biochemistry, 2009 Mar 3. PMID 19196006, Free PMC Article
  5. Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases. Parashar K, et al. Infect Immun, 2017 Sep. PMID 28630061, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.
    Title: UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.
  2. Bone marrow-derived dendritic cells (BMDCs) lacking ubiquitin associated and SH3 domain containing A (Sts-2) expression have an enhanced ability to inhibit Candida albicans growth and contribute significantly to the resistance of Sts-/- mice. Within BMDCs, the Sts phosphatases negatively regulate the activation of select pathways downstream of the key fungal pathogen pattern recognition receptor Dectin-1.
    Title: Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans.
  3. STS-2 suppresses development of collagen-induced arthritis.
    Title: Suppressor of TCR signaling-2 (STS-2) suppresses arthritis development in mice.
  4. Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.
    Title: Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.
  5. Sts-1 and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
    Title: Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.
  6. Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.
    Title: The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
  7. The lack of TULA facilitates T-cell responses to TCR/CD3 stimulation, thus exacerbating T-cell-dependent inflammation.
    Title: Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo.
  8. Skeletal analysis of mice that do not express TULA or TULA-2 proteins (DKO mice) revealed that there was a decrease in bone volume due to increased osteoclast numbers and function.
    Title: TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
  9. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
    Title: Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
  10. Sts-2(phosphoglycerate mutase) adopts the conformation of an active phosphatase whose activity is fundamentally different from that of Sts-1 despite the strong structural homology.
    Title: Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
NOT acts_upstream_of_or_within collagen-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin-associated and SH3 domain-containing protein A
Names
T-cell ubiquitin ligand 1
suppressor of T-cell receptor signaling 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177823.4 → NP_808491.2  ubiquitin-associated and SH3 domain-containing protein A

    See identical proteins and their annotated locations for NP_808491.2

    Status: VALIDATED

    Source sequence(s)
    AK040572, BB736706, BC027561, BY227020
    Consensus CDS
    CCDS50054.1
    UniProtKB/Swiss-Prot
    Q3TED7, Q3V3E1
    Related
    ENSMUSP00000158544.2, ENSMUST00000236745.2
    Conserved Domains (4) summary
    cd07040
    Location:361 → 456
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11937
    Location:241 → 300
    SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
    cd14300
    Location:25 → 61
    UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins
    pfam00300
    Location:413 → 575
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31426842..31478655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524434.5 → XP_006524497.1  ubiquitin-associated and SH3 domain-containing protein A isoform X1

    UniProtKB/TrEMBL
    A0A498WGR9
    Related
    ENSMUSP00000045890.9, ENSMUST00000048656.15
    Conserved Domains (3) summary
    cd07067
    Location:361 → 476
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11937
    Location:241 → 300
    SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
    cd14300
    Location:25 → 61
    UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins

RNA

  1. XR_003952136.2 RNA Sequence

  2. XR_876514.4 RNA Sequence

  3. XR_876515.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V3E1.1 GenPept UniProtKB/Swiss-Prot:Q3V3E1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous