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Bex6 brain expressed family member 6 [ Mus musculus (house mouse) ]

Gene ID: 328660, updated on 21-Apr-2024

Summary

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Official Symbol
Bex6provided by MGI
Official Full Name
brain expressed family member 6provided by MGI
Primary source
MGI:MGI:3588247
See related
Ensembl:ENSMUSG00000075269 AllianceGenome:MGI:3588247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B020003O03Rik
Summary
Predicted to enable alpha-tubulin binding activity and histone deacetylase binding activity. Predicted to be involved in several processes, including chromosome segregation; negative regulation of tubulin deacetylation; and regulation of cell migration. Located in cytoplasm. Is expressed in several structures, including Peyer's patch; alimentary system; brain; genitourinary system; and immune system. Orthologous to human BEX4 (brain expressed X-linked 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
16 B2; 16 22.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31998618..32005762)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32179800..32186944)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene centrosomal protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E4165 Neighboring gene STARR-seq mESC enhancer starr_40643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32130316-32130510 Neighboring gene negative regulator of reactive oxygen species Neighboring gene STARR-positive B cell enhancer ABC_E7441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177054-32177400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177409-32177592 Neighboring gene STARR-seq mESC enhancer starr_40648 Neighboring gene STARR-seq mESC enhancer starr_40649 Neighboring gene F-box protein 45 Neighboring gene STARR-positive B cell enhancer ABC_E10901 Neighboring gene predicted gene, 25848 Neighboring gene WD repeat domain 53

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunolocalization of Bex protein in the mouse brain and olfactory system. Koo JH, et al. J Comp Neurol, 2005 Jun 20. PMID 15861462
  2. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, et al. Gene, 2005 Aug 29. PMID 15958283
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein BEX6
Names
brain expressed gene 6
brain expressed, X-linked 6
brain-expressed X-linked protein 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033539.2 → NP_001028711.1  protein BEX6

    See identical proteins and their annotated locations for NP_001028711.1

    Status: PROVISIONAL

    Source sequence(s)
    AY833559
    Consensus CDS
    CCDS28116.1
    UniProtKB/Swiss-Prot
    A2RSJ0, Q3TZW7
    Related
    ENSMUSP00000156333.2, ENSMUST00000231941.2
    Conserved Domains (1) summary
    pfam04538
    Location:37 → 108
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31998618..32005762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TZW7.1 GenPept UniProtKB/Swiss-Prot:Q3TZW7

Gene LinkOut

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