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Parp4 poly (ADP-ribose) polymerase family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 328417, updated on 5-Mar-2024

Summary

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Official Symbol
Parp4provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 4provided by MGI
Primary source
MGI:MGI:2685589
See related
Ensembl:ENSMUSG00000054509 AllianceGenome:MGI:2685589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PH5P; p193; ARTD4; Gm743; PARPL; VPARP; PARP-4; VAULT3; Adprtl1; C030027K23Rik; E230037B21Rik
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Predicted to be involved in several processes, including inflammatory response; protein mono-ADP-ribosylation; and regulation of telomerase activity. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in cytosol and spindle microtubule. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.9), placenta adult (RPKM 4.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Parp4 in Genome Data Viewer
Location:
14 C3; 14 28.31 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56812982..56897256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56575619..56659798)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 17 Neighboring gene predicted gene, 50496 Neighboring gene predicted gene, 24392 Neighboring gene STARR-seq mESC enhancer starr_36796 Neighboring gene centromere protein J Neighboring gene STARR-positive B cell enhancer ABC_E10828 Neighboring gene STARR-positive B cell enhancer ABC_E5442 Neighboring gene predicted gene 16573 Neighboring gene STARR-positive B cell enhancer ABC_E755 Neighboring gene basic transcription factor 3, pseudogene 18 Neighboring gene M-phase phosphoprotein 8 Neighboring gene predicted gene, 16973

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Raval-Fernandes S, et al. Cancer Res, 2005 Oct 1. PMID 16204055
  2. Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Liu Y, et al. Mol Cell Biol, 2004 Jun. PMID 15169895, Free PMC Article
  3. The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Vezzali R, et al. Oncotarget, 2016 Jun 21. PMID 27224923, Free PMC Article
  4. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  5. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within telomere maintenance via telomerase IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in spindle TAS
Traceable Author Statement
more info
 PubMed 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP4
Names
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1
ADP-ribosyltransferase diphtheria toxin-like 4
mVparp
poly [ADP-ribose] polymerase 4
vault poly(ADP-ribose) polymerase
NP_001139450.2
XP_036014573.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145978.2 → NP_001139450.2  protein mono-ADP-ribosyltransferase PARP4

    Status: VALIDATED

    Source sequence(s)
    AC154731, AK053992, AK164513, AK172907
    Consensus CDS
    CCDS49503.1
    UniProtKB/Swiss-Prot
    E9PYK3, Q6A0B1, Q80UW6, Q8BW82, Q8R3A5
    Related
    ENSMUSP00000124258.2, ENSMUST00000161553.2
    Conserved Domains (7) summary
    smart00292
    Location:4 → 81
    BRCT; breast cancer carboxy-terminal domain
    smart00327
    Location:870 → 1026
    VWA; von Willebrand factor (vWF) type A domain
    cd01437
    Location:244 → 557
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    TIGR03788
    Location:629 → 1174
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam00644
    Location:371 → 559
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam06346
    Location:1394 → 1608
    Drf_FH1; Formin Homology Region 1
    pfam08487
    Location:616 → 724
    VIT; Vault protein inter-alpha-trypsin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56812982..56897256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158680.1 → XP_036014573.1  protein mono-ADP-ribosyltransferase PARP4 isoform X1

    Conserved Domains (3) summary
    smart00327
    Location:167 → 323
    VWA; von Willebrand factor (vWF) type A domain
    pfam06346
    Location:746 → 915
    Drf_FH1; Formin Homology Region 1
    cl02699
    Location:1 → 23
    VIT; Vault protein inter-alpha-trypsin domain

RNA

  1. XR_383191.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PYK3.1 GenPept UniProtKB/Swiss-Prot:E9PYK3

Gene LinkOut

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