Tsf1 Transferrin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tsf1provided by FlyBase
Official Full Name: Transferrin 1provided by FlyBase
Primary source: FLYBASE:FBgn0022355
Locus tag: Dmel_CG6186
See related: AllianceGenome:FB:FBgn0022355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 143958_at; anon-EST:Posey265; CG6186; Dmel\CG6186; lincRNA.S9601; Tf; Trf; tsf1; TSF1
Summary: Predicted to enable iron ion binding activity. Involved in olfactory behavior. Located in extracellular region and plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including atransferrinemia; carcinoma (multiple); glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human LTF (lactotransferrin); MELTF (melanotransferrin); and TF (transferrin). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18387084..18390344)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18281117..18284377)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.
Title: Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.
Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster.
Title: Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fungus	HEP more info	PubMed

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

Names: CG6186-PA; CG6186-PC; DTAF-transferrin; Transferrin1; Tsf1-PA; Tsf1-PC; transferrin; transferrin precursor

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The following sections contain reference sequences that belong to a specific genome build. Explain